Psychiatric disorders after deep brain stimulation of the subthalamic nucleus in Parkinson's disease: a systematic review.

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL
Einstein-Sao Paulo Pub Date : 2024-07-19 eCollection Date: 2024-01-01 DOI:10.31744/einstein_journal/2024RW0182
Caio de Almeida Lellis, Marco Alejandro Menacho Herbas, Ledismar José da Silva
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引用次数: 0

Abstract

Objective: To evaluate the psychiatric alterations resulting from deep brain stimulation of the subthalamic nucleus in the management of Parkinson's disease.

Methods: Articles were searched using three databases: Public/Publisher MEDLINE, Virtual Health Library, and Cochrane Library.

Results: Eleven studies were included in the analysis. Manic syndrome alone was reported in two of the 11 studies analyzed. Psychosis alone was not reported in any of them, but it was found in association with other psychiatric alterations in two studies, not including manic syndrome. In one case report, hypersexuality was associated with depression and self-alienation. Depressive disorder was the most frequent psychiatric disorder after deep brain stimulation of the subthalamic nucleus, according to five of the reviewed articles, encompassing 26 patients. In four of these articles, depression was associated with other psychiatric disorders, such as psychosis, suicidal ideation, hypersexuality, and anxiety. Hypomanic syndrome was reported in two cases.

Conclusion: More common psychiatric disorders related to the neuroanatomy of the nucleus were observed, probably because of the microlesions caused by the implantation of deep brain stimulation and the regulation of the stimulation of the device. The most common disorders include depression, mania/hypomania, psychosis, anxiety, suicidal ideation, and hypersexuality.

帕金森病患者眼下核深部脑刺激术后的精神障碍:系统综述。
目的评估在治疗帕金森病过程中对眼下核进行深部脑刺激所导致的精神改变:方法:使用三个数据库检索文章:方法:使用三个数据库检索文章:公共/出版商 MEDLINE、虚拟健康图书馆和 Cochrane 图书馆:结果:11 项研究被纳入分析。在所分析的 11 项研究中,有两项研究仅报告了躁狂综合征。其中没有一项研究单独报道了精神病,但有两项研究发现精神病与其他精神改变有关,其中不包括躁狂综合征。在一份病例报告中,性欲亢进与抑郁和自我疏远有关。根据五篇综述文章(共涉及 26 名患者),抑郁障碍是对眼下核进行深部脑刺激后最常见的精神疾病。在其中四篇文章中,抑郁症与其他精神疾病有关,如精神病、自杀意念、性欲亢进和焦虑。结论:与神经系统相关的精神疾病更为常见:结论:观察到与神经核神经解剖学有关的精神障碍更为常见,这可能是由于植入脑深部刺激装置和调节装置刺激所造成的微裂隙。最常见的疾病包括抑郁症、躁狂症/狂躁症、精神病、焦虑症、自杀倾向和性欲亢进。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Einstein-Sao Paulo
Einstein-Sao Paulo MEDICINE, GENERAL & INTERNAL-
CiteScore
2.00
自引率
0.00%
发文量
210
审稿时长
38 weeks
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