Preventable Fraction in the Context of Disease Progression.

IF 4.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Epidemiology Pub Date : 2024-11-01 Epub Date: 2024-07-23 DOI:10.1097/EDE.0000000000001770
Bronner P Gonçalves, Etsuji Suzuki
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引用次数: 0

Abstract

The relevance of the epidemiologic concept of preventable fraction to the study of the population-level impact of preventive exposures is unequivocal. Here, we discuss how the preventable fraction can be usefully understood for the class of outcomes that relate to disease progression (e.g., clinical severity given diagnosis), and, under the principal stratification framework, derive an expression for this quantity for this type of outcome. In particular, we show that, in the context of disease progression, the preventable fraction is a function of the effect on the postdiagnosis outcome in the principal stratum in the unexposed group who would have disease regardless of exposure status. This work will facilitate an understanding of the contribution of principal effects to the impact of preventive exposures at the population level.

在疾病进展过程中可预防的分数。
可预防分数这一流行病学概念对于研究预防性暴露对人群的影响具有明确的意义。在此,我们将讨论如何有效地理解与疾病进展相关的一类结果(如确诊时的临床严重程度)的可预防分数,并在主要分层框架下推导出这类结果的可预防分数表达式。特别是,我们表明,在疾病进展的背景下,可预防部分是对未暴露组主要分层中诊断后结果的影响的函数,而未暴露组无论暴露状况如何都会患病。这项工作将有助于理解主要效应对人群预防性暴露影响的贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Epidemiology
Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
6.70
自引率
3.70%
发文量
177
审稿时长
6-12 weeks
期刊介绍: Epidemiology publishes original research from all fields of epidemiology. The journal also welcomes review articles and meta-analyses, novel hypotheses, descriptions and applications of new methods, and discussions of research theory or public health policy. We give special consideration to papers from developing countries.
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