Sex differences in CGRP-induced vasodilation of human middle meningeal arteries but not human coronary arteries: implications for migraine.

IF 5 2区医学 Q1 CLINICAL NEUROLOGY

Cephalalgia Pub Date : 2024-07-01 DOI:10.1177/03331024241254088

Tessa de Vries, Deirdre M Boucherie, Kayi Y Chan, Eloísa Rubio-Beltrán, Alejandro Labastida-Ramírez, Sieneke Labruijere, Saurabh Gupta, Antoon van den Bogaerdt, Arnaud Vincent, Ruben Dammers, A H Jan Danser, Antoinette MaassenVanDenBrink

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引用次数: 0

Abstract

Background: Migraine prevalence and levels of calcitonin gene-related peptide (CGRP), a peptide involved in migraine pathophysiology, differ between men and women, and appear to be affected by changes in sex hormones. The present study investigated the sex-specific responses to CGRP in human isolated arteries.

Methods: CGRP-induced relaxation of 62 (28 men and 34 women) human isolated middle meningeal arteries (HMMA) and 139 (69 men and 70 women) human isolated coronary arteries (HCA) was compared between men and women in groups <50 years and ≥50 years of age as a proxy for pre- and postmenopausal status in women, as well as matched-age groups for men.

Results: In HCA, no differences were observed between male and female tissue, or between the different age groups. However, in HMMA, the maximum response was significantly smaller and CGRP was less potent in females <50 compared with males <50 years of age. No differences were observed between the older age groups.

Conclusions: Sex differences were observed for CGRP-induced relaxation of HMMA, but not HCA. These differences could arise from differential receptor expression in the vascular beds combined with the effect of sex hormones on CGRP and subsequent receptor desensitization.

查看原文本刊更多论文

CGRP 诱导的人类中脑膜动脉血管扩张的性别差异，而非人类冠状动脉：对偏头痛的影响。

背景：偏头痛的发病率和降钙素基因相关肽（CGRP）（一种参与偏头痛病理生理学的多肽）的水平在男性和女性之间存在差异，并且似乎受到性激素变化的影响。本研究调查了人离体动脉对 CGRP 的性别特异性反应：方法：比较 62 组（28 名男性和 34 名女性）人离体脑膜中动脉（HMMA）和 139 组（69 名男性和 70 名女性）人离体冠状动脉（HCA）在 CGRP 诱导下的松弛情况：在 HCA 中，未观察到男性和女性组织之间或不同年龄组之间存在差异。然而，在 HMMA 中，女性的最大反应明显较小，CGRP 的作用也较弱：在 CGRP 诱导的 HMMA 松弛中观察到了性别差异，但在 HCA 中没有观察到。这些差异可能源于血管床中不同的受体表达，以及性激素对 CGRP 的影响和随后的受体脱敏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cephalalgia 医学-临床神经学

CiteScore

10.10

自引率

6.10%

发文量

108

审稿时长

4-8 weeks

期刊介绍： Cephalalgia contains original peer reviewed papers on all aspects of headache. The journal provides an international forum for original research papers, review articles and short communications. Published monthly on behalf of the International Headache Society, Cephalalgia''s rapid review averages 5 ½ weeks from author submission to first decision.