Umbilical cord blood as a substitute for neonatal blood in measuring serum albumin and immunoglobulin G levels.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-07-23 DOI:10.1093/ajcp/aqae089

Toshihiko Ikuta, Sota Iwatani, Seiji Yoshimoto

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引用次数: 0

Abstract

Objectives: In this study, we investigated the clinical feasibility of using umbilical cord blood as an alternative to neonatal blood for measuring serum albumin and immunoglobulin G (IgG) levels in newborns, including preterm newborns.

Methods: Serum levels of albumin and IgG were measured in cord and neonatal blood from singleton newborns. We analyzed correlations and systematic errors between cord and neonatal blood measurements, stratifying the results for very preterm newborns (VPNs) born at a gestational age of less than 32 weeks and non-VPNs born at a gestational age of 32 weeks or later.

Results: Among all 494 newborns (78 VPNs and 416 non-VPNs), serum albumin and IgG levels were determined for 95.7% and 88.7% of them, respectively. Strong correlations between cord and neonatal blood were observed for the serum albumin and IgG levels (rs = 0.864 and 0.966, respectively). Moreover, the measurement errors between cord and neonatal blood were small for all newborns (0.2 g/dL and 65 mg/dL, respectively). These findings were consistent with both VPNs and non-VPNs.

Conclusions: Umbilical cord blood is a suitable substitute for neonatal blood in measuring serum albumin and IgG levels in newborns, even in premature newborns.

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用脐带血替代新生儿血液测量血清白蛋白和免疫球蛋白 G 水平。

研究目的本研究探讨了用脐带血替代新生儿血液测量新生儿（包括早产儿）血清白蛋白和免疫球蛋白 G（IgG）水平的临床可行性：方法：我们测量了单胎新生儿脐带血和新生儿血中的血清白蛋白和 IgG 水平。我们分析了脐带血和新生儿血液测量结果之间的相关性和系统误差，并对胎龄小于 32 周的极早产新生儿（VPN）和胎龄在 32 周或 32 周以上的非早产新生儿进行了分层：在所有 494 名新生儿（78 名 VPN 和 416 名非 VPN）中，分别有 95.7% 和 88.7% 的新生儿检测到血清白蛋白和 IgG 水平。脐带血和新生儿血液中的血清白蛋白和 IgG 水平之间存在很强的相关性（rs = 0.864 和 0.966）。此外，所有新生儿的脐带血和新生儿血的测量误差都很小（分别为 0.2 克/分升和 65 毫克/分升）。这些结果与 VPN 和非 VPN 一致：结论：在测量新生儿血清白蛋白和 IgG 水平时，脐带血是新生儿血液的合适替代品，早产儿也不例外。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464