Involvement of the gut microbiome-brain axis in alcohol use disorder.

IF 2.1 4区 医学 Q3 SUBSTANCE ABUSE
Sophie Leclercq
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引用次数: 0

Abstract

The human intestine is colonized by a variety of microorganisms that influence the immune system, the metabolic response, and the nervous system, with consequences for brain function and behavior. Unbalance in this microbial ecosystem has been shown to be associated with psychiatric disorders, and altered gut microbiome composition related to bacteria, viruses, and fungi has been well established in patients with alcohol use disorder. This review describes the gut microbiome-brain communication pathways, including the ones related to the vagus nerve, the inflammatory cytokines, and the gut-derived metabolites. Finally, the potential benefits of microbiota-based therapies for the management of alcohol use disorder, such as probiotics, prebiotics, and fecal microbiota transplantation, are also discussed.

肠道微生物-大脑轴参与酒精使用障碍。
人体肠道内有多种微生物,它们影响免疫系统、新陈代谢反应和神经系统,并对大脑功能和行为产生影响。这种微生物生态系统的失衡已被证明与精神疾病有关,而与细菌、病毒和真菌有关的肠道微生物组组成的改变已在酒精使用障碍患者中得到证实。这篇综述介绍了肠道微生物组与大脑的沟通途径,包括与迷走神经、炎症细胞因子和肠道衍生代谢物有关的途径。最后,还讨论了基于微生物群的疗法(如益生菌、益生元和粪便微生物群移植)在治疗酒精使用障碍方面的潜在益处。
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来源期刊
Alcohol and alcoholism
Alcohol and alcoholism 医学-药物滥用
CiteScore
4.70
自引率
3.60%
发文量
62
审稿时长
4-8 weeks
期刊介绍: About the Journal Alcohol and Alcoholism publishes papers on the biomedical, psychological, and sociological aspects of alcoholism and alcohol research, provided that they make a new and significant contribution to knowledge in the field. Papers include new results obtained experimentally, descriptions of new experimental (including clinical) methods of importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are considered equally with papers dealing with experimental work provided that such theoretical contributions are not of a largely speculative or philosophical nature.
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