The Efficacy of C-Reactive Protein (CRP) to Albumin Ratio (CAR) and Fibrinogen to CRP Ratio (FCR) in Predicting the Latent Period of Preterm Labor

IF 2.5 3区医学 Q3 IMMUNOLOGY

American Journal of Reproductive Immunology Pub Date : 2024-07-23 DOI:10.1111/aji.13899

Zeynep Seyhanli, Burak Bayraktar, Betul Tokgoz Cakir, Mevlut Bucak, Gulsan Karabay, Gizem Aktemur, Ayse Yigit, Kadriye Yakut Yucel, Zehra Vural Yılmaz

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引用次数: 0

Abstract

Objective

To investigate the role of inflammatory markers, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR), c-reactive protein (CRP) to albumin ratio (CAR), fibrinogen to albumin ratio (FAR), and fibrinogen to CRP ratio (FCR) in predicting the latency period (≤72 vs. >72 hours) before preterm birth.

Materials and Methods

In a retrospective study, we assessed 135 patients meeting the specified criteria with signs of preterm labor (<34 weeks). The patients were categorized into two groups: 71 patients giving birth within 72 h (latency ≤ 72 h) and 64 patients giving birth after 72 h (latency > 72 h). We examined the demographic and medical characteristics and perinatal outcomes of all participants. Categorical variables between groups were compared using the Chi-square test. The Student's t-test was utilized for normally distributed continuous variables, and the Mann–Whitney U test was applied for non-normally distributed data. Receiver operating characteristic (ROC) curve analysis was conducted to identify the optimal cut-off levels for inflammatory markers in predicting the latency period before birth.

Results

Among the parameters examined, significant differences were observed between the groups only in terms of CAR and FCR. While CAR showed a significantly higher value in the group with latency period ≤72 h (0.537 ± 1.239 vs. 0.247 ± 0.325, p = 0.022), FCR showed a significantly lower value in the group with latency period ≤72 h (63.58 (2.99–1165) vs. 88.93 (9.35–1165), p = 0.013). The identified cut-off value for CAR was 0.190, providing a sensitivity of 57.7% and a specificity of 56.3% (p = 0.022). The cut-off value for FCR was 71.67, with a sensitivity of 42.3% and a specificity of 42.2% (p = 0.013).

Conclusions

The CAR and the FCR, serving as predictive markers for preterm labor, may offer a simple, cost-effective, and easily accessible approach, particularly in resource-limited settings.

查看原文本刊更多论文

C 反应蛋白 (CRP) 与白蛋白比值 (CAR) 和纤维蛋白原与 CRP 比值 (FCR) 在预测早产潜伏期方面的功效。

目的研究炎症指标（包括中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、单核细胞与淋巴细胞比值（MLR）、c 反应蛋白（CRP）与白蛋白比值（CAR）、纤维蛋白原与白蛋白比值（FAR）、纤维蛋白原与 CRP 比值（FCR））在预测早产前潜伏期（≤72 小时与 >72 小时）中的作用：在一项回顾性研究中，我们对 135 名符合特定标准且有早产迹象（72 小时）的患者进行了评估。我们检查了所有参与者的人口统计学特征、医学特征和围产期结局。组间分类变量的比较采用卡方检验（Chi-square test）。对正态分布的连续变量采用学生 t 检验，对非正态分布的数据采用 Mann-Whitney U 检验。为了确定炎症标志物预测产前潜伏期的最佳临界值，进行了接收者操作特征曲线（ROC）分析：在检查的各项参数中，只有 CAR 和 FCR 在组间存在显著差异。潜伏期≤72小时组的CAR值明显更高（0.537 ± 1.239 vs. 0.247 ± 0.325，p = 0.022），而潜伏期≤72小时组的FCR值明显更低（63.58 (2.99-1165) vs. 88.93 (9.35-1165)，p = 0.013）。确定的 CAR 临界值为 0.190，灵敏度为 57.7%，特异度为 56.3%（p = 0.022）。FCR 的临界值为 71.67，灵敏度为 42.3%，特异度为 42.2%（p = 0.013）：作为早产的预测指标，CAR 和 FCR 可提供一种简单、经济、易行的方法，尤其是在资源有限的环境中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.20

自引率

5.60%

发文量

314

审稿时长

2 months

期刊介绍： The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.