Brain neuroplasticity in multiple sclerosis patients in functional magnetic resonance imaging. Part 1: Comparison with healthy volunteers.

Abstract

Purpose: The aim of this study was to assess the activity of motor cortical areas and the resting brain activity in a group of multiple sclerosis (MS) patients compared to a group of healthy individuals according to task-based functional magnetic resonance imaging (t-fMRI), resting state functional MRI (rs-fMRI), and volumetric MRI studies.

Material and methods: The study enrolled 28 MS patients and 20 healthy volunteers who underwent MRI examinations. Primary motor cortex (M1), premotor area (PMA), supplementary motor area, as well as resting state networks (RSN's) and volumes of selected brain structures were subjected to a detailed analysis.

Results: In MS patients, a motor task more often resulted in the activation of ipsilateral M1 cortex (observed in 39% of the studied group) as well as the PMA cortex (observed in 32% of MS patients). No differences in resting brain activity were found between the studied groups. Significant differences were observed in volumetric parameters of the total brain volume (healthy volunteers vs. MS patients, respectively): (1197 cm³ vs. 1150 cm³) and volumes of the grey matter (517 cm³ vs. 481 cm³), cerebellum (150 cm³ vs. 136 cm³), thalamus (16.3 cm³ vs. 12.6 cm³), putamen (8.9 cm³ vs. 7.7 cm³), and globus pallidus (4.57 cm³ vs. 3.57 cm³).

Conclusions: In the MS patients, the motor task required significantly more frequent activation of the primary and secondary ipsilateral motor cortex compared to the group of healthy volunteers. The rs-fMRI study showed no differences in activity patterns within the RSN's. Differences in the total cerebral volume and the volume of the grey matter, cerebellum, thalamus, putamen, and globus pallidus were observed.