Family History of Stroke Is Associated with Large- and Small-Vessel Etiology: A Systematic Review and Meta-Analysis.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY

Neuroepidemiology Pub Date : 2024-07-22 DOI:10.1159/000540085

Michał Błaż, Iwona Sarzyńska-Długosz

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引用次数: 0

Abstract

Background: Several studies have investigated the association between family history of stroke (FHS) and stroke etiology, recurrence, or mortality; however, the results have been discrepant. We conducted a systematic review with meta-analysis to further evaluate the associations.

Materials and methods: We searched Scopus database using the term "family history" AND "stroke" up to December 2023 to identify observational studies and systematic reviews reporting both the prevalence of FHS and the rates of stroke etiology or recurrence or mortality. Case reports, series, and narrative reviews were excluded. We used odds ratio (OR) as a common measure of association and I2 to determine heterogeneity of effects across studies.

Results: We have identified 22 articles (130,999 patients, 53% female), which met the prespecified inclusion criteria. After pooling the results, FHS was associated with large-vessel (OR, 1.24, 95% CI [1.07-1.44]), as well as small-vessel (OR, 1.17, 95% CI [1.05-1.31]), but not cardioembolic stroke etiology (OR, 0.74, 95% CI [0.60-0.90]). There was no relationship between FHS and stroke recurrence (OR, 1.16, 96% CI [0.84-1.61]), nor mortality (0.94, 95% CI [0.63-1.41]).

Conclusions: FHS is associated with large- and small-vessel stroke etiology, but not stroke recurrence or mortality. These findings might be useful to physicians caring for stroke patients in their everyday practice.

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中风家族史与大血管和小血管病因相关：系统回顾和荟萃分析。

背景：有多项研究调查了卒中家族史（FHS）与卒中病因、复发或死亡率之间的关系，但结果并不一致。我们进行了一项荟萃分析系统综述，以进一步评估二者之间的关联：我们在 Scopus 数据库中使用 "家族史 "和 "卒中 "这两个词进行了检索，检索时间截至 2023 年 12 月，目的是找出报道家族史患病率和卒中病因、复发率或死亡率的观察性研究和系统综述。病例报告、系列研究和叙述性综述均被排除在外。我们使用几率比作为衡量关联性的通用指标，并使用 I2 来确定各研究间效应的异质性：我们确定了 22 篇文章（130 999 名患者，53% 为女性）符合预先规定的纳入标准。汇总结果后，FHS 与大血管（OR，1.24，95%CI [1.07-1.44]）和小血管（OR，1.17，95%CI [1.05-1.31]）相关，但与心肌栓塞性卒中病因无关（OR，0.74，95%CI [0.60-0.90]）。FHS与中风复发（OR，1.16，96%CI [0.84-1.61]）和死亡率（0.94，95%CI [0.63-1.41]）之间没有关系：结论：FHS 与大血管和小血管卒中病因有关，但与卒中复发或死亡率无关。结论：FHS 与大血管和小血管卒中病因有关，但与卒中复发或死亡率无关。这些发现可能对日常护理卒中患者的医生有用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroepidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

9.90

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroepidemiology'' is the only internationally recognised peer-reviewed periodical devoted to descriptive, analytical and experimental studies in the epidemiology of neurologic disease. The scope of the journal expands the boundaries of traditional clinical neurology by providing new insights regarding the etiology, determinants, distribution, management and prevention of diseases of the nervous system.