Association between Physical Activity and Parkinson's Disease: A Prospective Cohort Study.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY

Neuroepidemiology Pub Date : 2024-07-22 DOI:10.1159/000540397

Qilu Zhang, Mengyao Shi, Jing Zhang, Xiangyan Yin, Yi Chen, Xiaoxiao Wang, Yonghong Zhang

{"title":"Association between Physical Activity and Parkinson's Disease: A Prospective Cohort Study.","authors":"Qilu Zhang, Mengyao Shi, Jing Zhang, Xiangyan Yin, Yi Chen, Xiaoxiao Wang, Yonghong Zhang","doi":"10.1159/000540397","DOIUrl":null,"url":null,"abstract":"Background: The burden of Parkinson's disease (PD) is still increasing, and physical activity is a modifiable factor for health benefits. The benefits of physical activity in PD are not well established. Therefore, this study aimed to investigate the association between various types of physical activity and the risk of developing PD.Methods: Data from 432,497 participants in UK Biobank, who were free of PD at baseline, were analyzed. Physical activity levels were assessed by measuring the duration of walking for pleasure, light and heavy do-it-yourself (DIY) activities, strenuous sports, and other exercises. Physical activity was categorized into daily living activities (walking for pleasure, light DIY, and heavy DIY) and structured exercises (strenuous sports and other exercises). Association between different types of physical activity and PD risk was examined using multivariable adjusted restricted cubic splines and Cox proportional risk models.Results: Over a median follow-up of 13.7 years, 2,350 PD cases were identified. Cubic spline analyses revealed negative linear associations between PD risk and total physical activity, daily living activities, and structured exercise. After multivariable adjustment, the hazard ratios and 95% confidence intervals for incident PD associated with the highest quartile of total physical activity, daily living activities, and structured exercise were 0.72 (0.64-0.81), 0.75 (0.67-0.84), and 0.78 (0.67-0.90), respectively, compared to those in the lowest quartile. Sensitivity analysis confirmed these findings.Conclusions: Higher levels of both daily living activities and structured exercise were associated with a reduced incidence of PD, underscoring the importance of maintaining physical activity to prevent PD.","PeriodicalId":54730,"journal":{"name":"Neuroepidemiology","volume":null,"pages":null},"PeriodicalIF":3.2000,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuroepidemiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000540397","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: The burden of Parkinson's disease (PD) is still increasing, and physical activity is a modifiable factor for health benefits. The benefits of physical activity in PD are not well established. Therefore, this study aimed to investigate the association between various types of physical activity and the risk of developing PD.

Methods: Data from 432,497 participants in UK Biobank, who were free of PD at baseline, were analyzed. Physical activity levels were assessed by measuring the duration of walking for pleasure, light and heavy do-it-yourself (DIY) activities, strenuous sports, and other exercises. Physical activity was categorized into daily living activities (walking for pleasure, light DIY, and heavy DIY) and structured exercises (strenuous sports and other exercises). Association between different types of physical activity and PD risk was examined using multivariable adjusted restricted cubic splines and Cox proportional risk models.

Results: Over a median follow-up of 13.7 years, 2,350 PD cases were identified. Cubic spline analyses revealed negative linear associations between PD risk and total physical activity, daily living activities, and structured exercise. After multivariable adjustment, the hazard ratios and 95% confidence intervals for incident PD associated with the highest quartile of total physical activity, daily living activities, and structured exercise were 0.72 (0.64-0.81), 0.75 (0.67-0.84), and 0.78 (0.67-0.90), respectively, compared to those in the lowest quartile. Sensitivity analysis confirmed these findings.

Conclusions: Higher levels of both daily living activities and structured exercise were associated with a reduced incidence of PD, underscoring the importance of maintaining physical activity to prevent PD.

查看原文本刊更多论文

体育锻炼与帕金森病的关系：前瞻性队列研究

背景：帕金森病（Parkinson's disease，PD）的发病率仍在上升，而体育锻炼是一个可改变健康状况的因素。体育锻炼对帕金森病的益处尚未得到充分证实。因此，本研究旨在调查各种类型的体育锻炼与帕金森病发病风险之间的关系：方法：分析了英国生物库中 432,497 名参与者的数据，这些参与者在基线时均未患有帕金森病。体力活动水平是通过测量快乐步行、轻度和重度DIY活动、剧烈运动和其他锻炼的持续时间来评估的。体力活动分为日常生活活动（散步消遣、轻度 DIY 和重度 DIY）和结构性锻炼（剧烈运动和其他锻炼）。采用多变量调整限制性三次样条模型和 Cox 比例风险模型对不同类型的体力活动与帕金森病风险之间的关系进行了研究：结果：在中位 13.7 年的随访中，共发现了 2350 例脊髓灰质炎病例。立方样条分析表明，帕金森病风险与总体力活动、日常生活活动和结构化锻炼之间存在负线性关系。经多变量调整后，与总体力活动、日常生活活动和结构化锻炼的最高四分位数相比，发生脊髓灰质炎的危险比和95%置信区间分别为0.72（0.64-0.81）、0.75（0.67-0.84）和0.78（0.67-0.90），与最低四分位数相比，发生脊髓灰质炎的危险比和95%置信区间分别为0.72（0.64-0.81）、0.75（0.67-0.84）和0.78（0.67-0.90）。敏感性分析证实了这些结果：结论：较高水平的日常生活活动和有组织的锻炼与帕金森病发病率的降低有关，强调了保持体育锻炼对预防帕金森病的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neuroepidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

9.90

自引率

1.80%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Neuroepidemiology'' is the only internationally recognised peer-reviewed periodical devoted to descriptive, analytical and experimental studies in the epidemiology of neurologic disease. The scope of the journal expands the boundaries of traditional clinical neurology by providing new insights regarding the etiology, determinants, distribution, management and prevention of diseases of the nervous system.