Maternal micronutrient biomarkers and risk of non-syndromic cleft lip/palate: A case-control study.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-07-22 DOI:10.1111/odi.15079

Araya Pisek, Christy M McKinney, Benja Muktabhant, Waranuch Pitiphat

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引用次数: 0

Abstract

Objective: This case-control study investigated the associations between maternal plasma vitamin B12, homocysteine, and red blood cell (RBC) folate levels and the risk of cleft lip with or without cleft palate (CL/P) in offspring.

Subjects and methods: The study compared 94 mothers and children with non-syndromic CL/P from a teaching hospital in Thailand to 94 mother-infant controls from local well-baby clinics, frequency-matched by birth date and mother's education. Data included anthropometric measurements, blood sample analyses, and a questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) estimated the associations through multiple logistic regression, adjusting for confounders.

Results: Mothers with higher plasma vitamin B12 levels had a lower risk of having a child with CL/P compared to those in the lowest quartile. This association was more pronounced among mothers without a family history of orofacial clefts and those who were not underweight. Conversely, elevated homocysteine levels, a marker of impaired B vitamin metabolism, increased the risk of CL/P. No association was found between RBC folate and CL/P.

Conclusion: Higher maternal vitamin B12 levels are associated with a reduced risk of CL/P, while elevated homocysteine levels may increase the risk.

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母体微量营养素生物标志物与非综合征唇腭裂风险：病例对照研究

研究目的这项病例对照研究调查了母体血浆维生素 B12、同型半胱氨酸和红细胞（RBC）叶酸水平与后代患唇裂伴或不伴腭裂（CL/P）风险之间的关系：该研究将泰国一家教学医院的94名非综合征CL/P母亲和患儿与当地健康婴儿诊所的94名母婴对照组进行了比较，并根据出生日期和母亲的教育程度进行了频率匹配。数据包括人体测量、血样分析和问卷调查。在对混杂因素进行调整的基础上，通过多元逻辑回归估算了相关关系的比率（ORs）和95%置信区间（CIs）：结果：与血浆维生素 B12 水平最低的母亲相比，血浆维生素 B12 水平较高的母亲生育 CL/P 患儿的风险较低。这种关联在没有口面裂家族史和体重不轻的母亲中更为明显。相反，同型半胱氨酸水平升高（B 族维生素代谢受损的标志）会增加罹患 CL/P 的风险。红细胞叶酸与 CL/P 之间没有关联：结论：母体维生素 B12 水平较高与 CL/P 风险降低有关，而同型半胱氨酸水平升高可能会增加 CL/P 风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.

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