Understanding the link between aspartame and cancer.

IF 2.9 3区医学 Q2 ONCOLOGY

Expert Review of Anticancer Therapy Pub Date : 2024-09-01 Epub Date: 2024-07-31 DOI:10.1080/14737140.2024.2383675

Morando Soffritti

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引用次数: 0

Abstract

Introduction: Aspartame, invented in 1965 by GD-Searle, is an intense artificial sweetener taste approximately 200 times as sweet as sucrose and used as an additive in more than 6,000 products. Aspartame (APM) was submitted for pre-marketing safety evaluation in early 1980. The studies, performed by GD-Searle, produced controversial results.

Areas covered: Because of the great commercial diffusion of aspartame, in 1997 the Ramazzini Institute (RI) started a large experimental project on rodents to test the carcinogenic effects of aspartame following an experimental model with more sensitive characteristics, namely a large number of rat and mice, starting treatment from prenatal life, observation until spontaneous death. Overall, the project included studying 2270 rats and 852 mice. These studies have shown that aspartame is a carcinogenic agent in experimental animals, inducing a significant dose-related increased incidence of several types of malignant tumors and, among them, hematological neoplasia, and liver cancer.

Expert opinion: The results of these studies on aspartame by the Ramazzini Institute opened a real front on the evaluation of artificial sweeteners and their possible health risks. Adequate long-term carcinogenicity bioassays on other diffuse artificial sweeteners such as acesulfame-k, sucralose, saccharin, including their blends, are likewise important for public health.

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了解阿司巴甜与癌症之间的联系。

简介阿斯巴甜由 GD-Searle 于 1965 年发明，是一种味道浓烈的人造甜味剂，甜度约为蔗糖的 200 倍，被用作 6,000 多种产品的添加剂。阿斯巴甜（APM）于 1980 年初提交上市前安全评估。由 GD-Searle 公司进行的研究得出了有争议的结果：由于阿斯巴甜在商业上的广泛传播，拉马齐尼研究所（RI）于 1997 年启动了一项大型啮齿动物实验项目，以测试阿斯巴甜的致癌作用，该项目采用了一种具有更敏感特征的实验模型，即大量的大鼠和小鼠，从出生前开始治疗，观察直至自然死亡。该项目共研究了 2270 只大鼠和 852 只小鼠。这些研究表明，阿斯巴甜在实验动物中是一种致癌物质，会诱发多种类型的恶性肿瘤，其中血液肿瘤和肝癌的发病率会随着剂量的增加而显著增加：拉马齐尼研究所对阿斯巴甜的这些研究结果为评估人工甜味剂及其可能的健康风险开辟了一条真正的道路。对安赛蜜、三氯蔗糖、糖精等其他扩散性人工甜味剂（包括它们的混合物）进行充分的长期致癌生物测定，对公众健康同样重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Anticancer Therapy 医学-肿瘤学

CiteScore

5.10

自引率

3.00%

发文量

100

审稿时长

4-8 weeks

期刊介绍： Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.