Melanoma and cannabinoids: A possible chance for cancer treatment

IF 3.5 3区医学 Q1 DERMATOLOGY

Experimental Dermatology Pub Date : 2024-07-23 DOI:10.1111/exd.15144

Mariarosaria Galeano, Federico Vaccaro, Natasha Irrera, Emanuela Caradonna, Francesco Borgia, Federica Li Pomi, Francesco Squadrito, Mario Vaccaro

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Abstract

The endocannabinoid system is composed by a complex and ubiquitous network of endogenous lipid ligands, enzymes for their synthesis and degradation, and receptors, which can also be stimulated by exogenous compounds, such as those derived from the Cannabis sativa. Cannabis and its bioactive compounds, including cannabinoids and non-cannabinoids, have been extensively studied in different conditions. Recent data have shown that the endocannabinoid system is responsible for maintaining the homeostasis of various skin functions such as proliferation, differentiation and release of inflammatory mediators. Because of their role in regulating these key processes, cannabinoids have been studied for the treatment of skin cancers and melanoma; their anti-tumour effects regulate skin cancer progression and are mainly related to the inhibition of tumour growth, proliferation, invasion and angiogenesis, through apoptosis and autophagy induction. This review aims at summarising the current field of research on the potential uses of cannabinoids in the melanoma field.

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黑色素瘤与大麻素：治疗癌症的可能机会

内源性大麻素系统是由内源性脂质配体、合成和降解这些配体的酶以及受体组成的一个复杂而无处不在的网络。大麻及其生物活性化合物，包括大麻素和非大麻素，已在不同条件下得到广泛研究。最近的数据显示，内源性大麻素系统负责维持各种皮肤功能的平衡，如增殖、分化和炎症介质的释放。由于大麻素在调节这些关键过程中的作用，大麻素已被研究用于治疗皮肤癌和黑色素瘤；其抗肿瘤作用可调节皮肤癌的进展，主要与通过诱导细胞凋亡和自噬抑制肿瘤生长、增殖、侵袭和血管生成有关。本综述旨在总结目前有关大麻素在黑色素瘤领域潜在用途的研究领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Dermatology 医学-皮肤病学

CiteScore

6.70

自引率

5.60%

发文量

201

审稿时长

2 months

期刊介绍： Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.