New Insights into Removing Antibiotic Resistance Genes: Environmental Factors, Technical Means, and Molecular Mechanisms

IF 6.4 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Current Pollution Reports Pub Date : 2024-07-18 DOI:10.1007/s40726-024-00320-y

Li Pan, Ziye Yang, Liming Liu, Liqun Chen, Can Wang

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引用次数: 0

Abstract

Purpose of Review

Antibiotic resistance has become a significant challenge around the world, and antibiotic resistance genes (ARGs) have also been recognized as emerging pollutants because of their wide distribution and adverse impacts on human health. Several approaches have been proposed to alleviate ARGs. However, limited knowledge exists on the summary of various strategies and their differences. To resolve these issues, we reviewed the elimination effects of ARGs in different ways and clarified the main molecular mechanisms.

Recent Findings

ARGs resistant to tetracyclines (tet) and sulfonamides (sul) have been found in many locations. In addition, various environmental factors, such as temperature, pH, and salinity may influence the removal of ARGs. Various traditional, emerging, and combined approaches have been used to eliminate ARGs, mainly associated with DNA damage, decrease in reactive oxygen species levels, and downregulated expression of ARGs-related function genes.

Summary

Collectively, this review systematically summarizes the environmental factors and strategies for ARGs removal. A comparison among these methods is made with a focus on performance and efficiency. Furthermore, we elucidate the main molecular mechanisms to eliminate ARGs. Ultimately, in terms of current studies, several advisable suggestions are proposed for further work.

Graphical Abstract

Abstract Image

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消除抗生素耐药基因的新见解：环境因素、技术手段和分子机制

综述目的抗生素耐药性已成为全球面临的一项重大挑战，抗生素耐药基因（ARGs）也因其广泛分布和对人类健康的不利影响而被视为新兴污染物。人们提出了几种方法来缓解 ARGs。然而，人们对各种策略的总结及其差异的了解还很有限。为了解决这些问题，我们回顾了不同方法消除 ARGs 的效果，并阐明了主要的分子机制。最近的研究结果在许多地方都发现了对四环素类（tet）和磺胺类（sul）耐药的 ARGs。此外，温度、pH 值和盐度等各种环境因素也可能影响 ARGs 的清除。本综述系统地总结了去除 ARGs 的环境因素和策略。本综述系统地总结了去除 ARGs 的环境因素和策略，并对这些方法的性能和效率进行了比较。此外，我们还阐明了消除 ARGs 的主要分子机制。最后，就目前的研究而言，为进一步的工作提出了一些可取的建议。

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来源期刊

Current Pollution Reports Environmental Science-Water Science and Technology

CiteScore

12.10

自引率

1.40%

发文量

期刊介绍： Current Pollution Reports provides in-depth review articles contributed by international experts on the most significant developments in the field of environmental pollution.By presenting clear, insightful, balanced reviews that emphasize recently published papers of major importance, the journal elucidates current and emerging approaches to identification, characterization, treatment, management of pollutants and much more.