Konjac glucomannan: A functional biopolymer for multifaceted drug delivery applications

IF 3.1 4区工程技术 Q2 POLYMER SCIENCE

Polymers for Advanced Technologies Pub Date : 2024-07-20 DOI:10.1002/pat.6512

Deepak Kulkarni, Vinit Agnihotri, Somnath Bhinge, Mayuri Ban, Dipak Bari, Chandrakantsing V. Pardeshi

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Abstract

Konjac glucomannan (KGM) is a hydrophilic, neutral polysaccharide obtained from the corm of Amorphophallus konjac (Araceae). Excellent biodegradability, biocompatibility, and nontoxicity has marked the utilization of KGM in variety of drug delivery and biomedical applications. KGM has generally regarded as safe (GRAS) status approved by the United States Food and Drug Administration. The gelling, and film‐forming properties possessed by native KGM has attracted a widespread attention of the researchers for exploring its drug delivery potential. Additionally, the versatility of KGM modifications further extends the drug delivery opportunities through ever‐increasing array of functional properties of KGM. Present review is aimed at presenting the state‐of‐the‐art collection of structure, functional properties, biosynthesis, in vitro and in vivo degradation, chemical modifications, and finally, the drug delivery applications of the KGM. Authors tried to cover the aspects of the KGM relevant to the formulation personnel, and academicians involved in the investigation on variety of pharmaceutical, biotechnological, and biomedical applications of KGM. This article may encourage the investigators to explore the use of KGM, owing to its beneficial traits, as pharmaceutical excipient for drug delivery applications.

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魔芋葡甘聚糖：用于多方面药物输送的功能性生物聚合物

魔芋葡甘露聚糖（KGM）是一种亲水性中性多糖，从魔芋（天南星科植物）的子实体中提取。KGM 具有良好的生物降解性、生物相容性和无毒性，因此被广泛应用于各种药物输送和生物医学领域。KGM 已获得美国食品和药物管理局的普遍安全（GRAS）认证。原生 KGM 所具有的胶凝和成膜特性吸引了研究人员对其药物输送潜力的广泛关注。此外，KGM改性的多功能性通过不断增加KGM的一系列功能特性，进一步拓展了药物输送的机会。本综述旨在介绍最新的 KGM 结构、功能特性、生物合成、体外和体内降解、化学修饰以及给药应用。作者试图涵盖与制剂人员和参与研究 KGM 的各种制药、生物技术和生物医学应用的学者相关的 KGM 方面的内容。由于 KGM 具有有益的特性，这篇文章可能会鼓励研究人员探索将 KGM 作为药用辅料用于给药应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polymers for Advanced Technologies 工程技术-高分子科学

CiteScore

6.20

自引率

5.90%

发文量

337

审稿时长

2.1 months

期刊介绍： Polymers for Advanced Technologies is published in response to recent significant changes in the patterns of materials research and development. Worldwide attention has been focused on the critical importance of materials in the creation of new devices and systems. It is now recognized that materials are often the limiting factor in bringing a new technical concept to fruition and that polymers are often the materials of choice in these demanding applications. A significant portion of the polymer research ongoing in the world is directly or indirectly related to the solution of complex, interdisciplinary problems whose successful resolution is necessary for achievement of broad system objectives. Polymers for Advanced Technologies is focused to the interest of scientists and engineers from academia and industry who are participating in these new areas of polymer research and development. It is the intent of this journal to impact the polymer related advanced technologies to meet the challenge of the twenty-first century. Polymers for Advanced Technologies aims at encouraging innovation, invention, imagination and creativity by providing a broad interdisciplinary platform for the presentation of new research and development concepts, theories and results which reflect the changing image and pace of modern polymer science and technology. Polymers for Advanced Technologies aims at becoming the central organ of the new multi-disciplinary polymer oriented materials science of the highest scientific standards. It will publish original research papers on finished studies; communications limited to five typewritten pages plus three illustrations, containing experimental details; review articles of up to 40 pages; letters to the editor and book reviews. Review articles will normally be published by invitation. The Editor-in-Chief welcomes suggestions for reviews.