{"title":"A mechanically stable self-pumping organohydrogel dressing with aligned microchannels for accelerated diabetic wound healing","authors":"Wuyi Xiao, Xizi Wan, Yikai Zhang, Jinze Lan, Lianxin Shi, Shutao Wang","doi":"10.1007/s40843-024-2980-1","DOIUrl":null,"url":null,"abstract":"<p>Self-pumping dressings (SPDs) have been developed as a new type of effective material for the drainage of excessive wound exudates based on the structure of asymmetric wettability. However, current SPDs are easy to lose their asymmetric wettability due to the weak interfacial mechanical stability between the hydrophobic and hydrophilic layers. Herein, we report an integrated self-pumping organohydrogel dressing with aligned microchannels (SPD-AM), prepared by an ice-templating-assisted wetting-enabled-transfer (WET) polymerization strategy, that can accelerate the healing process of diabetic wounds. The WET polymerization strategy enables strong interfacial mechanical stability between the hydrophobic organogel and hydrophilic hydrogel layers. The aligned microchannels greatly improve the draining capability of SPDs. Taking a diabetic rat model as an example, the SPD-AM can significantly reduce the bacterial colonization with low inflammatory responses, enhance dermal remodeling by about 47.31%, and shorten wound closure time by about 1/5 compared with other dressings, ultimately accelerating diabetic wound healing. This study is valuable for developing next-generation SPDs with stable mechanical performance for clinical applications.</p>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":null,"pages":null},"PeriodicalIF":6.8000,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science China Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1007/s40843-024-2980-1","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Self-pumping dressings (SPDs) have been developed as a new type of effective material for the drainage of excessive wound exudates based on the structure of asymmetric wettability. However, current SPDs are easy to lose their asymmetric wettability due to the weak interfacial mechanical stability between the hydrophobic and hydrophilic layers. Herein, we report an integrated self-pumping organohydrogel dressing with aligned microchannels (SPD-AM), prepared by an ice-templating-assisted wetting-enabled-transfer (WET) polymerization strategy, that can accelerate the healing process of diabetic wounds. The WET polymerization strategy enables strong interfacial mechanical stability between the hydrophobic organogel and hydrophilic hydrogel layers. The aligned microchannels greatly improve the draining capability of SPDs. Taking a diabetic rat model as an example, the SPD-AM can significantly reduce the bacterial colonization with low inflammatory responses, enhance dermal remodeling by about 47.31%, and shorten wound closure time by about 1/5 compared with other dressings, ultimately accelerating diabetic wound healing. This study is valuable for developing next-generation SPDs with stable mechanical performance for clinical applications.
自泵送敷料(SPDs)是基于非对称润湿结构而开发的一种新型有效材料,可用于引流过多的伤口渗出物。然而,由于疏水层和亲水层之间的界面机械稳定性较弱,目前的自泵送敷料很容易失去其非对称润湿性。在此,我们报告了一种具有排列微通道的集成自泵送有机水凝胶敷料(SPD-AM),该敷料是通过冰-模板-辅助湿化-转移(WET)聚合策略制备的,可加速糖尿病伤口的愈合过程。WET 聚合策略使疏水有机凝胶层和亲水水凝胶层之间具有很强的界面机械稳定性。排列整齐的微通道大大提高了 SPD 的引流能力。以糖尿病大鼠模型为例,与其他敷料相比,SPD-AM 能在低炎症反应的情况下显著减少细菌定植,促进真皮重塑约 47.31%,缩短伤口闭合时间约 1/5,最终加速糖尿病伤口愈合。这项研究对开发具有稳定机械性能的下一代 SPD 临床应用具有重要价值。
期刊介绍:
Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.