{"title":"Bioinspired and bioengineered nucleic acid drug carriers","authors":"Jiamin Zuo, Zhiguo Lu, Jing Guo, Ruichen Zhao, Tianlu Zhang, Zhaoxia Wang, Yun Yuan, Jianwen Deng, Junliang Yuan, Xin Zhang","doi":"10.1007/s40843-024-2858-8","DOIUrl":null,"url":null,"abstract":"<p>Nucleic acid drugs have great potential in treating various diseases due to their advantage of directly acting on disease-causing genes. However, since they need to overcome multiple biological barriers to reach the target, they face many difficulties and challenges in practical applications. In order to improve the stability and delivery efficiency of nucleic acid drugs, researchers have begun to take advantage of the ability to deliver biomolecules endogenously, as possessed by bioengineered and bioinspired materials, for nucleic acid drug delivery. This paper focuses on the biological barriers that need to be overcome during the delivery of nucleic acid drugs and the advantages and applications of bioengineered and bioinspired materials in nucleic acid drug delivery. By utilizing these state-of-the-art biomaterials, researchers are expected to improve the therapeutic efficacy of nucleic acid drugs and provide a new solution for disease treatment.\n</p>","PeriodicalId":773,"journal":{"name":"Science China Materials","volume":null,"pages":null},"PeriodicalIF":6.8000,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science China Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1007/s40843-024-2858-8","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Nucleic acid drugs have great potential in treating various diseases due to their advantage of directly acting on disease-causing genes. However, since they need to overcome multiple biological barriers to reach the target, they face many difficulties and challenges in practical applications. In order to improve the stability and delivery efficiency of nucleic acid drugs, researchers have begun to take advantage of the ability to deliver biomolecules endogenously, as possessed by bioengineered and bioinspired materials, for nucleic acid drug delivery. This paper focuses on the biological barriers that need to be overcome during the delivery of nucleic acid drugs and the advantages and applications of bioengineered and bioinspired materials in nucleic acid drug delivery. By utilizing these state-of-the-art biomaterials, researchers are expected to improve the therapeutic efficacy of nucleic acid drugs and provide a new solution for disease treatment.
期刊介绍：
Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.
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