Recent advances and innovations in the design and fabrication of wearable flexible biosensors and human health monitoring systems based on conjugated polymers

IF 8.1 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Vinh Van Tran, Viet-Duc Phung, Daeho Lee
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Abstract

Wearable biosensors have received great interest as patient-friendly diagnostic technologies because of their high flexibility and conformability. The growing research and utilization of novel materials in designing wearable biosensors have accelerated the development of point-of-care sensing platforms and implantable biomedical devices in human health care. Among numerous potential materials, conjugated polymers (CPs) are emerging as ideal choices for constructing high-performance wearable biosensors because of their outstanding conductive and mechanical properties. Recently, CPs have been extensively incorporated into various wearable biosensors to monitor a range of target biomolecules. However, fabricating highly reliable CP-based wearable biosensors for practical applications remains a significant challenge, necessitating novel developmental strategies for enhancing the viability of such biosensors. Accordingly, this review aims to provide consolidated scientific evidence by summarizing and evaluating recent studies focused on designing and fabricating CP-based wearable biosensors, thereby facilitating future research. Emphasizing the superior properties and benefits of CPs, this review aims to clarify their potential applicability within this field. Furthermore, the fundamentals and main components of CP-based wearable biosensors and their sensing mechanisms are discussed in detail. The recent advancements in CP nanostructures and hybridizations for improved sensing performance, along with recent innovations in next-generation wearable biosensors are highlighted. CP-based wearable biosensors have been—and will continue to be—an ideal platform for developing effective and user-friendly diagnostic technologies for human health monitoring.

Graphic abstract

Abstract Image

设计和制造基于共轭聚合物的可穿戴柔性生物传感器和人体健康监测系统的最新进展与创新
可穿戴生物传感器因其高度的灵活性和适应性,作为方便病人的诊断技术受到了极大的关注。在设计可穿戴生物传感器时,对新型材料的研究和利用日益增多,加速了医疗点传感平台和植入式生物医学设备在人类医疗保健领域的发展。在众多潜在材料中,共轭聚合物(CPs)因其出色的导电性能和机械性能,正在成为构建高性能可穿戴生物传感器的理想选择。最近,共轭聚合物已被广泛用于各种可穿戴生物传感器,以监测一系列目标生物分子。然而,为实际应用制造高度可靠的基于氯化石蜡的可穿戴生物传感器仍然是一项重大挑战,因此有必要采用新的开发策略来提高此类生物传感器的可行性。因此,本综述旨在通过总结和评估近期有关设计和制造基于 CP 的可穿戴生物传感器的研究,提供综合的科学证据,从而促进未来的研究。本综述强调了氯化石蜡的优越性能和优点,旨在阐明其在该领域的潜在适用性。此外,还详细讨论了基于氯化石蜡的可穿戴生物传感器的基本原理和主要组成部分及其传感机制。重点介绍了为提高传感性能而在氯化石蜡纳米结构和杂化方面取得的最新进展,以及下一代可穿戴生物传感器的最新创新。基于氯化石蜡的可穿戴生物传感器已经成为并将继续成为开发有效和用户友好的人体健康监测诊断技术的理想平台。
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来源期刊
Bio-Design and Manufacturing
Bio-Design and Manufacturing Materials Science-Materials Science (miscellaneous)
CiteScore
13.30
自引率
7.60%
发文量
148
期刊介绍: Bio-Design and Manufacturing reports new research, new technology and new applications in the field of biomanufacturing, especially 3D bioprinting. Topics of Bio-Design and Manufacturing cover tissue engineering, regenerative medicine, mechanical devices from the perspectives of materials, biology, medicine and mechanical engineering, with a focus on manufacturing science and technology to fulfil the requirement of bio-design.
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