Tunable Zn-MOF-74 nanocarriers coated with sodium alginate as versatile drug carriers

IF 3.1 3区化学 Q2 POLYMER SCIENCE

Polymer Bulletin Pub Date : 2024-07-20 DOI:10.1007/s00289-024-05426-3

Amir Kazemi, Mohammad Hossein Afshari, Hasan Baesmat, Faranak Manteghi, Hafezeh Nabipour, Sohrab Rohani, Mohammad Reza Saeb

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Abstract

In this study, MOF-74 nanocarriers were coated with sodium alginate (SALG) to enhance physicochemical properties and biocompatibility. Spectroscopic and microscopic analyses showed MOF-74 particle size below 100 nm. Zinc-based MOF-74 nanocarriers (Zn-MOF-74) were developed for doxorubicin (DOX) delivery, achieving high drug loading efficiency (DLE) and drug loading capacity (DLC) as measured by UV–visible spectrometry. Nanocarriers synthesized using zinc acetate (R_A-MOF-74) achieved a DLE of 96.5% and a DLC of 19.6%, outperforming those prepared with zinc nitrate (R_N-MOF-74) with a DLE of 88.8% and a DLC of 18.3%. Uncoated samples released cargo rapidly at pH 1.5 and significantly at pH 8. In contrast, SALG-coated samples showed reduced release at pH 1.5 and reached 54.2% release at pH 8 due to alginate’s physicochemical properties. Drug release from DOX@R_A-MOF-74/ALG was significantly slower and more sustained than from uncoated samples. This study demonstrates the potential of SALG-coated R_A-MOF-74 as a controlled drug release system for biomedical applications.

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涂有海藻酸钠的可调 Zn-MOF-74 纳米载体作为多功能药物载体

在这项研究中，MOF-74 纳米载体涂覆了海藻酸钠（SALG），以增强其理化特性和生物相容性。光谱和显微分析表明，MOF-74 的粒径小于 100 nm。研究人员开发了锌基 MOF-74 纳米载体（Zn-MOF-74），用于多柔比星（DOX）的给药，并通过紫外可见光谱法测定了高载药效率（DLE）和载药量（DLC）。使用醋酸锌（RA-MOF-74）合成的纳米载体的载药效率为 96.5%，载药量为 19.6%，优于使用硝酸锌（RN-MOF-74）制备的纳米载体，后者的载药效率为 88.8%，载药量为 18.3%。未包覆的样品在 pH 值为 1.5 时药物释放迅速，在 pH 值为 8 时释放显著；相比之下，由于海藻酸盐的物理化学特性，SALG 包覆的样品在 pH 值为 1.5 时释放减少，在 pH 值为 8 时释放达到 54.2%。与未包衣样品相比，DOX@RA-MOF-74/ALG 的药物释放明显更慢、更持久。这项研究证明了 SALG 包覆的 RA-MOF-74 作为药物控释系统在生物医学应用方面的潜力。

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来源期刊

Polymer Bulletin 化学-高分子科学

CiteScore

6.00

自引率

6.20%

发文量

审稿时长

5.5 months

期刊介绍： "Polymer Bulletin" is a comprehensive academic journal on polymer science founded in 1988. It was founded under the initiative of the late Mr. Wang Baoren, a famous Chinese chemist and educator. This journal is co-sponsored by the Chinese Chemical Society, the Institute of Chemistry, and the Chinese Academy of Sciences and is supervised by the China Association for Science and Technology. It is a core journal and is publicly distributed at home and abroad. "Polymer Bulletin" is a monthly magazine with multiple columns, including a project application guide, outlook, review, research papers, highlight reviews, polymer education and teaching, information sharing, interviews, polymer science popularization, etc. The journal is included in the CSCD Chinese Science Citation Database. It serves as the source journal for Chinese scientific and technological paper statistics and the source journal of Peking University's "Overview of Chinese Core Journals."