Design and Functionality of Trypsin-Triggered, Expandable Bovine Serum Albumin-Polyethylene Glycol Diacrylate Hydrogel Actuators

IF 11.1 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Yuchen Liu, Luai R. Khoury
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引用次数: 0

Abstract

Expandable shape-morphing hydrogels that ensure prolonged site residence, have tailored mechanical integrity and tunability, are biocompatible to minimize side effects and can release drugs over an extended time remain challenging to achieve. Herein, a new class of enzyme-triggered bovine serum albumin and polyethylene glycol diacrylate hybrid hydrogels is presented, contributing to advancements in controlled drug-model release and actuation. These hydrogels combine the intrinsic properties of proteins with the resilience of synthetic polymers, offering a versatile application platform. Central to our research is the trypsin-induced simultaneous functionality of controlled drug model release and dynamic shape changes under physiological trypsin concentrations (0.01% w/v). These hydrogels display tailored mechanical and physical properties and microstructure, which are crucial for biomedical devices, soft robotics, and tissue engineering applications. Additionally, the hydrogels effectively control the release of fluorescein isothiocyanate, a model drug, indicating their potential for highly targeted drug delivery, particularly in the gastrointestinal tract. The study also highlights the significant effect of shape-morphing on drug release rates under physiological trypsin concentrations. These findings suggest that enzyme-responsive hybrid protein-polymer hydrogel actuators with tailored mechanical and physical properties can enhance the precision of drug delivery in biomedical applications.

Abstract Image

胰蛋白酶触发的可扩张牛血清白蛋白-聚乙二醇二丙烯酸酯水凝胶致动器的设计与功能
可扩展的形状-形态水凝胶可确保长时间的部位驻留、具有定制的机械完整性和可调性、具有生物兼容性以最大限度地减少副作用,并能长时间释放药物,但要实现这些目标仍具有挑战性。本文介绍了一类新型酶触发牛血清白蛋白和聚乙二醇二丙烯酸酯杂化水凝胶,有助于推进药物模型的可控释放和驱动。这些水凝胶结合了蛋白质的固有特性和合成聚合物的弹性,提供了一个多功能应用平台。我们研究的核心是在生理胰蛋白酶浓度(0.01% w/v)下,由胰蛋白酶诱导的药物模型可控释放和动态形状变化的同步功能。这些水凝胶具有量身定制的机械、物理特性和微观结构,这对于生物医学设备、软机器人和组织工程应用至关重要。此外,这些水凝胶还能有效控制模型药物异硫氰酸荧光素的释放,这表明它们具有高度靶向给药的潜力,尤其是在胃肠道。该研究还强调了在生理胰蛋白酶浓度下,形状变形对药物释放率的显著影响。这些研究结果表明,具有定制机械和物理特性的酶响应混合蛋白质聚合物水凝胶致动器可以提高生物医学应用中的药物输送精度。
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来源期刊
CiteScore
14.00
自引率
2.40%
发文量
0
期刊介绍: Small Science is a premium multidisciplinary open access journal dedicated to publishing impactful research from all areas of nanoscience and nanotechnology. It features interdisciplinary original research and focused review articles on relevant topics. The journal covers design, characterization, mechanism, technology, and application of micro-/nanoscale structures and systems in various fields including physics, chemistry, materials science, engineering, environmental science, life science, biology, and medicine. It welcomes innovative interdisciplinary research and its readership includes professionals from academia and industry in fields such as chemistry, physics, materials science, biology, engineering, and environmental and analytical science. Small Science is indexed and abstracted in CAS, DOAJ, Clarivate Analytics, ProQuest Central, Publicly Available Content Database, Science Database, SCOPUS, and Web of Science.
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