Abnormal Temporal Window of Integration in Auditory Sensory Memory in Schizophrenia.

Clinical EEG and neuroscience Pub Date : 2025-01-01 Epub Date: 2024-07-21 DOI:10.1177/15500594241263378
Ren Asai, Hirooki Yabe, Tomiharu Hiruma, Takashi Matsuoka, Haruko Asai, Etsuko Hara, Yuhei Mori, Ken Suzutani, Hiroshi Hoshino, Tetsuya Shiga, Itaru Miura, Koichi Hirata, Sunao Kaneko
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Abstract

Mismatch negativity (MMN) is automatically elicited by incoming sound deviation compared to the neural representation of preceding homogenous sounds stored in the brain's auditory sensory memory. This study aimed to assess time-functional deviation sensitivity in auditory sensory memory associated with a temporal window of integration (TWI) of 160-170 msec in patients with schizophrenia. To this end, we measured the magnetic counterpart of the MMN (MMNm) in 20 patients with schizophrenia on medication and 20 healthy age-matched adults as a control group responding to an omitted tone segment incorporated into a complex sound of 176 ms duration corresponding to the TWI duration. Overall, the magnitude of the MMNm was smaller in the patients with schizophrenia than in the healthy control group. The peak latency of the MMNm was prolonged in the latter omitted segments for both groups, but to a greater extent in patients with schizophrenia. These results indicate that deviation detection is impaired in the later part of the TWI, corresponding to the duration of auditory sensory memory in patients with schizophrenia. Thus, the specific impairment of MMN in response to duration deviants (duration MMN), as previously reported, might result from a damaged mechanism in the later part of the TWI of sensory memory, suggesting that a decline in sensory memory causes distorted perception or disturbances in cognitive function in patients with schizophrenia.

精神分裂症患者听觉感官记忆的异常时空整合窗口
错配负性(MMN)是由传入声音与大脑听觉记忆中存储的先前同质声音的神经表征相比出现偏差而自动引起的。本研究旨在评估精神分裂症患者听觉记忆中与 160-170 毫秒整合时间窗 (TWI) 相关的时间功能偏差敏感性。为此,我们测量了 20 名正在接受药物治疗的精神分裂症患者和 20 名年龄匹配的健康成人作为对照组,他们在对一个被省略的音段做出反应时,MMN 的磁性对应物(MMNm)与 TWI 时长相对应,被省略的音段包含在一个持续时间为 176 毫秒的复合声音中。总体而言,精神分裂症患者 MMNm 的幅度小于健康对照组。两组患者的 MMNm 峰值潜伏期在后省略音段中都有所延长,但精神分裂症患者的延长程度更大。这些结果表明,精神分裂症患者的偏差检测在 TWI 的后半部分受损,这与听觉记忆的持续时间相对应。因此,正如之前所报道的那样,MMN 对持续时间偏差(持续时间 MMN)的特定反应障碍可能是由感觉记忆 TWI 后半部分的受损机制造成的,这表明感觉记忆的衰退会导致精神分裂症患者的感知失真或认知功能紊乱。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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