Pharmacogenetics of therapies in rheumatoid arthritis: An update.

IF 4.5 2区 医学 Q1 RHEUMATOLOGY
Mohamed H Babiker-Mohamed, Sambhawana Bhandari, Prabha Ranganathan
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引用次数: 0

Abstract

Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory arthritis. Despite many treatment advances, achieving remission or low-disease activity in RA remains challenging, often requiring trial and error approaches with numerous medications. Precision medicine, particularly pharmacogenomics, explores how genetic factors influence drug response in individual patients, and incorporates such factors to develop personalized treatments for individual patients. Genetic variations in drug-metabolizing enzymes, transporters, and targets may contribute to inter-individual differences in drug efficacy and toxicity. Advancements in molecular sequencing have allowed rapid identification of such variants, including single nucleotide polymorphisms (SNPs). This review highlights recent major findings in the pharmacogenetics of therapies in RA, focusing on key genes and SNPs to provide insights into current trends and developments in this field.

类风湿性关节炎的药物遗传学疗法:最新进展。
类风湿性关节炎(RA)是一种全身性自身免疫性炎症性关节炎。尽管在治疗方面取得了许多进展,但要实现类风湿关节炎的缓解或低疾病活动度仍然具有挑战性,往往需要使用多种药物进行反复试验。精准医学,尤其是药物基因组学,探索遗传因素如何影响个体患者对药物的反应,并结合这些因素为个体患者开发个性化治疗方法。药物代谢酶、转运体和靶点的基因变异可能导致药物疗效和毒性的个体差异。分子测序技术的进步使得包括单核苷酸多态性(SNPs)在内的此类变异得以快速鉴定。这篇综述重点介绍了最近在RA药物遗传学治疗方面的主要发现,重点关注关键基因和SNPs,以便深入了解该领域当前的趋势和发展。
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来源期刊
CiteScore
9.40
自引率
0.00%
发文量
43
审稿时长
27 days
期刊介绍: Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.
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