Multimodal Analysis of the Retinal Manifestations of Tuberous Sclerosis Complex: A Case Series.

IF 0.9 4区医学 Q4 OPHTHALMOLOGY

Ophthalmic surgery, lasers & imaging retina Pub Date : 2024-10-01 Epub Date: 2024-07-01 DOI:10.3928/23258160-20240523-03

Matthew M O'Riordan, Claire Behan, Fionn O'Leary, Natalie Hudson, Colin P Doherty, Mark T Cahill, Matthew Campbell

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引用次数: 0

Abstract

Background and objective: We used a multi-modal imaging approach including fundus fluorescein angiography (FFA) to assess the retinal lesions in tuberous sclerosis complex (TSC) and evaluate their correlation with intracranial tuber burden on magnetic resonance imaging (MRI).

Patients and methods: Participants with TSC underwent bilateral fundus photography, optical coherence tomography (OCT), infrared (IR) imaging, and FFA. Participants' most recent MRI brain scans were analyzed to determine intracranial tuber load.

Results: Nine participants were included. OCT identified all retinal astrocytic hamartoma (RAH) lesions, IR identified 75%, fundus photography identified 63%, and FFA detected just 57%. On FFA, 20% of flat-type hamartomas and all multi-nodular and transitional types were hyperfluorescent. There were significant positive correlations between the quantities of intracranial tubers and all TSC-retinal lesions (r = 0.8, P < 0.01) and all RAH lesions (r = 0.8, P = 0.01).

Conclusions: A multimodal imaging-based approach with fundal photography, IR imaging, and OCT should be used to assess the retina in TSC as it may indicate the intracranial tuber burden. [Ophthalmic Surg Lasers Imaging Retina 2024;55:568-574.].

查看原文本刊更多论文

结节性硬化综合征视网膜表现的多模态分析：病例系列。

背景和目的：我们采用包括眼底荧光素血管造影（FFA）在内的多模态成像方法评估结节性硬化综合征（TSC）的视网膜病变，并评估其与磁共振成像（MRI）上颅内结节负荷的相关性：TSC患者接受双侧眼底照相、光学相干断层扫描（OCT）、红外成像（IR）和FFA检查。对参与者最近的核磁共振脑部扫描进行分析，以确定颅内结节负荷：结果：共纳入九名参与者。OCT 发现了所有视网膜星形细胞瘤（RAH）病变，IR 发现了 75%，眼底摄影发现了 63%，而 FFA 仅发现了 57%。在 FFA 检测中，20% 的扁平型仓瘤以及所有多结节型和过渡型仓瘤呈高荧光。颅内管瘤的数量与所有TSC视网膜病变（r = 0.8，P < 0.01）和所有RAH病变（r = 0.8，P = 0.01）之间存在明显的正相关性：结论：应使用眼底照相、红外成像和OCT等多模态成像方法来评估TSC视网膜，因为它可以显示颅内结节的负担。[眼科手术激光成像视网膜2024;55:XX-XX]。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmic surgery, lasers & imaging retina OPHTHALMOLOGY-SURGERY

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.