Honghua Zhang , Shaoxian Liang , Kewan Yin , Yufeng Mo , Yamin Li , Yaning Lv , Hao Zhan , Zhuang Zhang , Zhilei Shan , Zhiguo Guo , Shi Yin , Wanshui Yang
{"title":"Urinary Equol and Equol-Predicting Microbial Genera Are Favorably Associated with Body Fat Measures among Chinese Adults","authors":"Honghua Zhang , Shaoxian Liang , Kewan Yin , Yufeng Mo , Yamin Li , Yaning Lv , Hao Zhan , Zhuang Zhang , Zhilei Shan , Zhiguo Guo , Shi Yin , Wanshui Yang","doi":"10.1016/j.tjnut.2024.07.024","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Many studies have investigated the intake of dietary isoflavones in relation to obesity risk, whereas the association using objective biomarkers of isoflavones, particularly equol (a gut-derived metabolite of daidzein with greater bioavailability than other isoflavones) has been less studied. In addition, the associations between equol and gut microbiota profile at the population level remain to be fully characterized.</p></div><div><h3>Objectives</h3><p>We aimed to identify equol-predicting microbial species and to investigate the associations of equol-predicting microbial species and urinary excretion of isoflavones including glycitein, genistein, daidzein, and equol with diverse obesity markers in free living-individuals.</p></div><div><h3>Methods</h3><p>In this 1-y longitudinal study of 754 community-dwelling adults, urinary isoflavones, fecal microbiota, height, weight, and circumferences of waist and hip were measured at baseline and again after 1 y. Liver fat [indicated by the controlled attenuation parameter (CAP)] and other body composition were also measured after 1 y. Linear models and linear mixed-effects models were used to analyze the associations for single measure and repeated measures, respectively.</p></div><div><h3>Results</h3><p>Among 305 participants (median age: 50 y, IQR, 37–59 y) including 138 males and 167 females, higher urinary excretion of equol was associated with lower CAP (<em>β</em> = −0.013, <em>P</em> < 0.001) and body fat mass (<em>β</em>= −0.014, <em>P</em> = 0.046). No association was found between any other urinary isoflavones and obesity markers (all <em>P</em> > 0.05). We identified 21 bacterial genera whose relative abundance were positively associated with urinary equol concentrations (all <em>P</em><sub>false</sub> <sub>discovery rate</sub> < 0.05), and constructed an equol-predicting microbial score to reflect the overall equol-producing potential of host gut microbiota. This score was inversely associated with CAP (<em>β</em> = −0.040, <em>P</em> = 0.011).</p></div><div><h3>Conclusions</h3><p>High urinary equol concentrations and equol-predicting microbial species could be favorably associated with liver fat and other obesity markers.</p></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"154 9","pages":"Pages 2843-2851"},"PeriodicalIF":3.8000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nutrition","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S002231662400405X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Many studies have investigated the intake of dietary isoflavones in relation to obesity risk, whereas the association using objective biomarkers of isoflavones, particularly equol (a gut-derived metabolite of daidzein with greater bioavailability than other isoflavones) has been less studied. In addition, the associations between equol and gut microbiota profile at the population level remain to be fully characterized.
Objectives
We aimed to identify equol-predicting microbial species and to investigate the associations of equol-predicting microbial species and urinary excretion of isoflavones including glycitein, genistein, daidzein, and equol with diverse obesity markers in free living-individuals.
Methods
In this 1-y longitudinal study of 754 community-dwelling adults, urinary isoflavones, fecal microbiota, height, weight, and circumferences of waist and hip were measured at baseline and again after 1 y. Liver fat [indicated by the controlled attenuation parameter (CAP)] and other body composition were also measured after 1 y. Linear models and linear mixed-effects models were used to analyze the associations for single measure and repeated measures, respectively.
Results
Among 305 participants (median age: 50 y, IQR, 37–59 y) including 138 males and 167 females, higher urinary excretion of equol was associated with lower CAP (β = −0.013, P < 0.001) and body fat mass (β= −0.014, P = 0.046). No association was found between any other urinary isoflavones and obesity markers (all P > 0.05). We identified 21 bacterial genera whose relative abundance were positively associated with urinary equol concentrations (all Pfalsediscovery rate < 0.05), and constructed an equol-predicting microbial score to reflect the overall equol-producing potential of host gut microbiota. This score was inversely associated with CAP (β = −0.040, P = 0.011).
Conclusions
High urinary equol concentrations and equol-predicting microbial species could be favorably associated with liver fat and other obesity markers.
期刊介绍：
The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
