The effect of physical activity on glycaemic control in people with type 1 diabetes mellitus: A systematic literature review and meta-analysis

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetic Medicine Pub Date : 2024-07-21 DOI:10.1111/dme.15415

Diederik De Cock, Lucas Schreurs, Nele Steenackers, Sofia Pazmino, Wilfried Cools, Lauren Eykerman, Hannah Thiels, Chantal Mathieu, Bart Van der Schueren

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引用次数: 0

Abstract

Aims

Type 1 diabetes mellitus (T1DM) is characterised by insulin deficiency. Due to perceived physical activity (PA)-related hypoglycaemia, a minority of people with T1DM exercise regularly. However, the relationship between T1DM and PA remains poorly understood. Our aim was to summarise the existing literature on the effects of PA on short-term glucose control (glycated haemoglobin or time in range) in people with T1DM.

Methods

We searched seven electronic databases (PubMed, Embase, Cochrane library, Cinahl, SPORTDiscus, PEDro and Web Of Science) and two sources of the grey literature (ClinicalTrials.gov and ICTRP). All reviews were screened via title/abstract and full text by two independent reviewers (LE and HT), conflicts were solved by a third independent reviewer (DDC). We excluded animal studies, case reports, non-English articles, qualitative studies, conference abstracts and articles without full-text access. A meta-analysis using random effects model was performed to study the effect of PA on haemoglobin A1c (HbA1c) levels in people with T1DM.

Results

We obtained 19,201 unique references across nine different electronic databases. After screening and snowballing, 68 articles were found investigating the effect of PA on glycaemic control in people with T1DM. Overall, HbA1c levels in the PA group (mean difference = 0.29% (0.20%–0.39%)), were lower compared with the control group.

Conclusion

An overall small beneficial effect of PA on glycaemic control in people with T1DM was found. Caution is advised when interpreting the results of this meta-analysis, given variations in study type, duration, frequency and intensity of physical activity across included studies.

Abstract Image

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体育锻炼对 1 型糖尿病患者血糖控制的影响：系统性文献综述和荟萃分析。

目的：1 型糖尿病（T1DM）的特点是胰岛素缺乏。由于认为体力活动（PA）会导致低血糖，少数 T1DM 患者会定期锻炼。然而，人们对 T1DM 与体力活动之间的关系仍然知之甚少。我们的目的是总结现有文献中有关 PA 对 T1DM 患者短期血糖控制（糖化血红蛋白或在范围内的时间）的影响：我们检索了七个电子数据库（PubMed、Embase、Cochrane library、Cinahl、SPORTDiscus、PEDro 和 Web Of Science）和两个灰色文献来源（ClinicalTrials.gov 和 ICTRP）。所有综述均由两名独立审稿人（LE 和 HT）通过标题/摘要和全文进行筛选，冲突由第三名独立审稿人（DDC）解决。我们排除了动物研究、病例报告、非英语文章、定性研究、会议摘要和无法获取全文的文章。采用随机效应模型进行荟萃分析，研究 PA 对 T1DM 患者血红蛋白 A1c（HbA1c）水平的影响：我们在九个不同的电子数据库中获得了 19201 条独特的参考文献。经过筛选和 "滚雪球 "式搜索，我们发现 68 篇文章调查了 PA 对 T1DM 患者血糖控制的影响。总体而言，与对照组相比，PA 组的 HbA1c 水平较低（平均差异 = 0.29% (0.20%-0.39%)）：结论：研究发现，PA 对 T1DM 患者的血糖控制总体上略有益处。由于纳入研究的研究类型、持续时间、运动频率和强度各不相同，因此在解释这项荟萃分析的结果时应谨慎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetic Medicine 医学-内分泌学与代谢

CiteScore

7.20

自引率

5.70%

发文量

229

审稿时长

3-6 weeks

期刊介绍： Diabetic Medicine, the official journal of Diabetes UK, is published monthly simultaneously, in print and online editions. The journal publishes a range of key information on all clinical aspects of diabetes mellitus, ranging from human genetic studies through clinical physiology and trials to diabetes epidemiology. We do not publish original animal or cell culture studies unless they are part of a study of clinical diabetes involving humans. Categories of publication include research articles, reviews, editorials, commentaries, and correspondence. All material is peer-reviewed. We aim to disseminate knowledge about diabetes research with the goal of improving the management of people with diabetes. The journal therefore seeks to provide a forum for the exchange of ideas between clinicians and researchers worldwide. Topics covered are of importance to all healthcare professionals working with people with diabetes, whether in primary care or specialist services. Surplus generated from the sale of Diabetic Medicine is used by Diabetes UK to know diabetes better and fight diabetes more effectively on behalf of all people affected by and at risk of diabetes as well as their families and carers.”