Delivering Microrobots in the Musculoskeletal System

IF 26.6 1区材料科学 Q1 Engineering

Nano-Micro Letters Pub Date : 2024-07-22 DOI:10.1007/s40820-024-01464-8

Mumin Cao, Renwang Sheng, Yimin Sun, Ying Cao, Hao Wang, Ming Zhang, Yunmeng Pu, Yucheng Gao, Yuanwei Zhang, Panpan Lu, Gaojun Teng, Qianqian Wang, Yunfeng Rui

引用次数: 0

Abstract

Highlights

A systematic review of recent advances of microrobots applied in the musculoskeletal system with an emphasis on design strategies of microrobotic systems for tissue regeneration.
The fabrication, motion and control, and image-guided delivery of microrobots in the musculoskeletal system are reviewed based on the up-to-date works.
Prospects and challenges for future clinical translation of microrobots in the musculoskeletal system and regenerative medicine are discussed.

Abstract Image

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在肌肉骨骼系统中输送微型机器人。

肌肉骨骼系统疾病是造成全球疾病负担的主要因素，而目前的治疗方法疗效有限。患者经常遭受慢性疼痛的折磨，最终可能不得不接受终末期手术。因此，未来的治疗应侧重于早期发现和干预区域病变。微型机器人具有智能、精确和微创靶向给药的优势，已逐渐应用于生物体内。通过与控制系统和成像系统的结合，具有良好生物安全性的微机器人可被输送到所需的区域进行治疗。在肌肉骨骼系统中，微机器人主要用于运送干细胞/药物或清除体内有害物质。与传统的生物材料和组织工程策略相比，主动运动提高了细胞/药物局部靶向的效率和穿透力。本综述讨论了微机器人系统在肌肉骨骼系统不同组织中的前沿应用。通过评估不同微型机器人的特点，我们总结了阻碍临床转化的挑战和障碍，最后指出了微型机器人在肌肉骨骼系统中的未来发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano-Micro Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

32.60

自引率

4.90%

发文量

981

审稿时长

1.1 months

期刊介绍： Nano-Micro Letters is a peer-reviewed, international, interdisciplinary, and open-access journal published under the SpringerOpen brand. Nano-Micro Letters focuses on the science, experiments, engineering, technologies, and applications of nano- or microscale structures and systems in various fields such as physics, chemistry, biology, material science, and pharmacy.It also explores the expanding interfaces between these fields. Nano-Micro Letters particularly emphasizes the bottom-up approach in the length scale from nano to micro. This approach is crucial for achieving industrial applications in nanotechnology, as it involves the assembly, modification, and control of nanostructures on a microscale.