Ionic covalent organic framework as photo-activated nitric oxide generator for cascaded gaseous, photothermal, photodynamic and cationic bactericidal synergistic therapy

IF 4.5 3区工程技术 Q1 CHEMISTRY, APPLIED

Reactive & Functional Polymers Pub Date : 2024-07-19 DOI:10.1016/j.reactfunctpolym.2024.106012

Qian Song , Guoli Sun , Qinghua Yu , Jie Yu , Dandan Xu , Guiyu Zhang , Dangui Wang , Weiwei Bian , Baolong Zhou

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Abstract

Despite great advances in bactericidal therapy, it is still hard to achieve satisfactory therapeutic effects using the single antibacterial modality nowadays, especially the emergence of drug-resistant bacteria. To address such challenge, a light-induced synergistic therapeutic platform was facilely constructed by incorporating sodium nitroprusside (SNP) into a biocompatible ionic covalent organic framework (COF), denoted as TD-COF, to combat the bacteria infection. Upon 638 nm laser irradiation, the positive charged therapeutic agents (TD-COF-SNP) with strong affinity to the negatively charged bacterial membrane could realize the photothermal-driven cascaded multimodal synergistic treatments, in which the local high temperature could not only induce the controllable generation of nitric oxide (NO), but also significantly accelerate the formation of reactive oxygen species (ROS) via the photodynamic therapy (PDT), destroying the pathogen structure, and killing pathogenic bacteria. Meanwhile, both the in vitro and in vivo assay revealed the synergistic NO/PTT/PDT/cationic triggered by laser irradiation was also highly effective for the treatment of infected wounds caused by bacteria. This work paves an avenue for the delicately design of COF-based solid state therapeutic agents toward bacteria infection treatment.

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离子共价有机框架作为光活化一氧化氮发生器，用于级联气态、光热、光动力和阳离子杀菌协同疗法

尽管杀菌疗法取得了巨大进步，但如今单一的抗菌方式仍难以达到令人满意的治疗效果，尤其是耐药菌的出现。为了应对这一挑战，我们将硝普钠（SNP）加入到生物相容性离子共价有机框架（COF）中，简便地构建了一个光诱导协同治疗平台（TD-COF），以对抗细菌感染。在 638 纳米激光照射下，带正电荷的治疗剂（TD-COF-SNP）与带负电荷的细菌膜具有很强的亲和力，可实现光热驱动的级联多模式协同治疗，其中局部高温不仅可诱导一氧化氮（NO）的可控生成，还可通过光动力疗法（PDT）显著加速活性氧（ROS）的形成，破坏病原体结构，杀灭病原菌。同时，体外和体内试验均显示，激光照射引发的 NO/PTT/PDT/ 阳离子协同作用对治疗细菌引起的感染伤口也非常有效。这项工作为微妙设计基于 COF 的固态治疗剂治疗细菌感染铺平了道路。

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来源期刊

Reactive & Functional Polymers 工程技术-高分子科学

CiteScore

8.90

自引率

5.90%

发文量

259

审稿时长

27 days

期刊介绍： Reactive & Functional Polymers provides a forum to disseminate original ideas, concepts and developments in the science and technology of polymers with functional groups, which impart specific chemical reactivity or physical, chemical, structural, biological, and pharmacological functionality. The scope covers organic polymers, acting for instance as reagents, catalysts, templates, ion-exchangers, selective sorbents, chelating or antimicrobial agents, drug carriers, sensors, membranes, and hydrogels. This also includes reactive cross-linkable prepolymers and high-performance thermosetting polymers, natural or degradable polymers, conducting polymers, and porous polymers. Original research articles must contain thorough molecular and material characterization data on synthesis of the above polymers in combination with their applications. Applications include but are not limited to catalysis, water or effluent treatment, separations and recovery, electronics and information storage, energy conversion, encapsulation, or adhesion.