Evaluation of contrast-enhanced ultrasound for predicting tumor grade in small (≤4 cm) clear cell renal cell carcinoma: Qualitative and quantitative analysis.

Clinical hemorheology and microcirculation Pub Date : 2024-07-17 DOI:10.3233/CH-231990

Ming Liang, Haolin Qiu, Bing Ou, Jiayi Wu, Xinbao Zhao, Baoming Luo

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Abstract

Objective: The study aimed to evaluate the utility of qualitative and quantitative analysis employing contrast-enhanced ultrasound (CEUS) in predicting the WHO/ISUP grade of small (≤4 cm) clear cell renal cell carcinoma (ccRCCs).

Methods: Patients with small ccRCCs, confirmed by histological examination, underwent preoperative CEUS and were classified into low- (grade I/II) and high-grade (grade III/IV) groups. Qualitative and quantitative assessments of CEUS were conducted and compared between the two groups. Diagnostic performance was assessed using receiver operating characteristic curves.

Results: A total of 72 patients were diagnosed with small ccRCCs, comprising 23 individuals in the high-grade group and 49 in the low-grade group. The low-grade group exhibited a significantly greater percentage of hyper-enhancement compared to the high-grade group (79.6% VS 39.1%, P < 0.05). The low-grade group showed significantly higher relative index values for peak enhancement, wash-in area under the curve, wash-in rate, wash-in perfusion index, and wash-out rate compared to the high-grade group (all P < 0.05). The AUC values for qualitative and quantitative parameters in predicting the WHO/ISUP grade of small ccRCCs ranged from 0.676 to 0.756.

Conclusions: Both qualitative and quantitative CEUS analysis could help to distinguish the high- from low-grade small ccRCCs.

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评估造影剂增强超声预测小细胞（≤4 厘米）透明细胞肾细胞癌的肿瘤分级：定性与定量分析

研究目的该研究旨在评估造影剂增强超声波（CEUS）的定性和定量分析在预测小型（≤4厘米）透明细胞肾细胞癌（ccRCC）的WHO/ISUP分级方面的实用性：经组织学检查确诊的小型ccRCC患者接受术前CEUS检查，并被分为低级别（I/II级）和高级别（III/IV级）两组。对CEUS进行定性和定量评估，并在两组之间进行比较。使用接收器操作特征曲线评估诊断效果：结果：共有72名患者被确诊为小型ccRCC，其中高级别组23人，低级别组49人。与高级别组相比，低级别组的高增强比例明显更高（79.6% VS 39.1%，P 结论：CEUS定性和定量CEUS均可用于诊断小型ccRCC：CEUS定性和定量分析有助于区分高级别和低级别小型ccRCC。

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Clinical hemorheology and microcirculation

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