Evaluation of SARS-Cov-2 neutralizing antibody among Sinopharm Vero Cell (BBIBP-CorV) vaccinated medical students.

Q3 Medicine

Human Antibodies Pub Date : 2024-01-01 DOI:10.3233/HAB-240029

Sony Khadka, Sanjib Mani Regmi, Nuwadatta Subedi, Arjun Poudel, Dhaka Ram Bhandari, Mitesh Karn, Shanti Pradhan, Prabin Shrestha

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Abstract

Background: Information regarding seropositivity and vaccine efficacy among medical students is scarce. This study aims to detect the status of SARS-CoV-2 neutralizing antibodies among the Sinopharm's Vero Cell (BBIBP-CorV) vaccinated medical students.

Materials and methods: A prospective, cross-sectional study was carried out among medical students of Gandaki Medical College Teaching Hospital, Pokhara, Nepal from March through August 2022. The level of SARS-CoV-2 serum- neutralizing IgG antibody was measured and its relation with participants' age and sex, duration of vaccination, and any comorbid condition was determined.

Results: A total of 110 medical students were included in the final analysis, the majority being females (65.5%) and the mean age is 23.1 ± 3.2 years. Most of the students (96.4%) had neutralizing antibodies against SARS-CoV-2. Among the 29 (26.36%) students who received a booster dose, the positivity rate was 100%. The mean IgG levels were 9.57 ± 9.58 μg/ml and 2.91 ± 2.47 μg/ml among students receiving an additional booster dose and among those not receiving it, respectively. In the cohort receiving a booster dose of the vaccine, the average value of neutralizing IgG antibodies was high. In contrast, the ones not receiving it, the titers were low and showed a declining trend.

Conclusion: Though the dose strategy of the Sinopharm vaccine is effective, booster vaccination may be an important strategy to ensure protection among medical students, who are at high risk of COVID-19 due to constant patient exposure during their training. Further studies should assess vaccine efficacy among individuals who received other vaccines as well.

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评估接种国药Vero细胞（BBIBP-CorV）疫苗的医学生的SARS-Cov-2中和抗体。

背景：有关医学生血清阳性和疫苗效力的信息很少。本研究旨在检测接种了国药集团 Vero 细胞（BBIBP-CorV）疫苗的医学生中 SARS-CoV-2 中和抗体的状况：2022 年 3 月至 8 月，在尼泊尔博卡拉甘达基医学院教学医院的医学生中开展了一项前瞻性横断面研究。测量了 SARS-CoV-2 血清中和 IgG 抗体的水平，并确定了其与参与者的年龄、性别、接种疫苗的时间以及任何合并症的关系：共有 110 名医科学生参与了最终分析，其中大多数为女性（65.5%），平均年龄为 23.1 ± 3.2 岁。大多数学生（96.4%）体内有针对 SARS-CoV-2 的中和抗体。在接受强化免疫的 29 名学生（26.36%）中，阳性率为 100%。接受额外强化免疫和未接受额外强化免疫的学生的平均 IgG 水平分别为 9.57 ± 9.58 μg/ml 和 2.91 ± 2.47 μg/ml。在接种了强化疫苗的学生群中，中和 IgG 抗体的平均值较高。结论：结论：尽管国药集团疫苗的剂量策略是有效的，但加强接种可能是确保医学生保护的重要策略，因为医学生在培训期间经常接触病人，是 COVID-19 的高危人群。进一步的研究还应评估接种过其他疫苗的人接种疫苗的效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Antibodies Medicine-Immunology and Allergy

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Human Antibodies is an international journal designed to bring together all aspects of human hybridomas and antibody technology under a single, cohesive theme. This includes fundamental research, applied science and clinical applications. Emphasis in the published articles is on antisera, monoclonal antibodies, fusion partners, EBV transformation, transfections, in vitro immunization, defined antigens, tissue reactivity, scale-up production, chimeric antibodies, autoimmunity, natural antibodies/immune response, anti-idiotypes, and hybridomas secreting interesting growth factors. Immunoregulatory molecules, including T cell hybridomas, will also be featured.