Benzimidazole scaffold as a potent anticancer agent with different mechanisms of action (2016-2023).

IF 3.9 2区化学 Q2 CHEMISTRY, APPLIED

Molecular Diversity Pub Date : 2024-07-20 DOI:10.1007/s11030-024-10907-8

Fatma Fouad Hagar, Samar H Abbas, Eman Atef, Dalia Abdelhamid, Mohamed Abdel-Aziz

引用次数: 0

Abstract

Benzimidazole scaffolds have potent anticancer activity due to their structure similarity to nucleoside. In addition, benzimidazoles could function as hydrogen donors or acceptors and bind to different drug targets that participate in cancer progression. The literature had many anticancer agents containing benzimidazole cores that gained much interest. Provoked by our endless interest in benzimidazoles as anticancer agents, we summarized the successful trials of the benzimidazole scaffolds in this concern. Moreover, we discuss the substantial opportunities in cancer treatment using benzimidazole-based drugs that may direct medicinal chemists for a compelling future design of more active chemotherapeutic agents with potential clinical applications. The uniqueness of this work lies in the highlighted benzimidazole scaffold hybridization with different molecules and benzimidazole-metal complexes, detailed mechanisms of action, and the IC₅₀ of the developed compounds determined by different laboratories after 2015.

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苯并咪唑支架作为一种具有不同作用机制的强效抗癌剂（2016-2023 年）。

苯并咪唑支架与核苷的结构相似，因此具有很强的抗癌活性。此外，苯并咪唑还可以作为氢供体或受体，与参与癌症进展的不同药物靶点结合。文献中许多含有苯并咪唑核心的抗癌药物都引起了人们的兴趣。由于我们对苯并咪唑类抗癌药物的无限兴趣，我们总结了苯并咪唑支架的成功试验。此外，我们还讨论了使用苯并咪唑类药物治疗癌症的巨大商机，这些商机可能会引导药物化学家在未来设计出具有潜在临床应用价值的更具活性的化疗药物。这项工作的独特之处在于强调了苯并咪唑支架与不同分子和苯并咪唑-金属复合物的杂交、详细的作用机制以及 2015 年后不同实验室测定的所开发化合物的 IC50。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Diversity 化学-化学综合

CiteScore

7.30

自引率

7.90%

发文量

219

审稿时长

2.7 months

期刊介绍： Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;