Exploring actigraphy as a digital phenotyping measure: A study on differentiating psychomotor agitation and retardation in depression

IF 5.3 2区医学 Q1 PSYCHIATRY

Acta Psychiatrica Scandinavica Pub Date : 2024-07-19 DOI:10.1111/acps.13739

Julia Maruani, Sibylle Mauries, Feriel Zehani, Michel Lejoyeux, Pierre A. Geoffroy

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引用次数: 0

Abstract

Introduction

Psychomotor activity stands out as a crucial symptom in characterizing behaviors associated with depression. This study aims to explore the potential of actigraphy as a tool for digital phenotyping in characterizing symptoms of psychomotor agitation and retardation, which are clinically challenging dimensions to capture, in patients diagnosed with major depressive episode (MDE) according to DSM-5 criteria.

Methods

We compared rest-activity circadian rhythm biomarkers measured by the Motion Watch 8 actigraphy between 58 (78.4%) patients with MDE and psychomotor retardation (PMR), and 16 (21.6%) patients with MDE and psychomotor agitation (PMA), according to DSM-5 criteria.

Results

Actigraphy allowed to objectively report PMA through heightened activity over a 24-h period, while PMR manifests as reduced activity during the most active 10 h. Lower rest-activity rhythm (RAR) amplitude in PMR was accompanied by increased irregularities in intra- and inter-day rhythms. Interestingly, actigraphy emerges as an objective tool to measure the characteristics of the active and rest periods, free from the confounding effects of sleep disturbances. Indeed, no differences in sleep disturbances were identified between patients exhibiting psychomotor agitation and those displaying PMR.

Conclusion

Digital phenotyping through actigraphy may aid in distinguishing psychomotor retardation and psychomotor agitation allowing for a more precise characterization of the depression phenotype. When integrated with clinical assessment, measurements from actigraphy could offer additional insights into activity rhythms alongside subjective assessments and hold the potential to augment existing clinical decision-making processes in psychiatry.

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探索作为数字表型测量方法的行为记录仪：区分抑郁症患者精神运动性躁动和迟缓的研究。

导言精神运动活动是描述抑郁症相关行为特征的一个重要症状。本研究旨在探索动觉仪作为数字表型工具在描述根据 DSM-5 标准诊断为重度抑郁发作（MDE）患者的精神运动性躁动和迟缓症状方面的潜力：根据DSM-5标准，我们比较了58例（78.4%）重度抑郁发作和精神运动迟滞（PMR）患者与16例（21.6%）重度抑郁发作和精神运动性躁动（PMA）患者使用Motion Watch 8动觉仪测量的休息-活动昼夜节律生物标记物：活动记录仪可通过 24 小时内的活动增加客观地报告 PMA，而 PMR 则表现为在最活跃的 10 小时内活动减少。PMR 的休息-活动节律（RAR）振幅较低，同时日内和日间节律的不规则性增加。有趣的是，活动记录仪是测量活动期和休息期特征的客观工具，不受睡眠干扰的影响。事实上，精神运动性躁动患者与 PMR 患者在睡眠障碍方面并无差异：结论：通过动图进行数字表型分析有助于区分精神运动迟滞和精神运动性躁动，从而更准确地描述抑郁症表型。当与临床评估相结合时，通过动作描记术进行的测量可在主观评估的基础上提供更多有关活动节律的见解，并有可能增强精神病学现有的临床决策过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Psychiatrica Scandinavica 医学-精神病学

CiteScore

11.20

自引率

3.00%

发文量

135

审稿时长

6-12 weeks

期刊介绍： Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.