{"title":"Interfacial energy-mediated stability of liquid barrier for sustainable and efficient anti-clogging of urinary catheter","authors":"","doi":"10.1016/j.nantod.2024.102412","DOIUrl":null,"url":null,"abstract":"<div><p>Catheter clogging by crystal biofilm always causes enormous economic burden and serious consequences. However, most researches mainly focus on anti-bacteria while neglecting the deposition of stone, which often protects encapsulated bacteria and accelerates catheter clogging. Inspired by Nepenthes pitcher, we herein present a bioinspired liquid barrier-infused coating (BLBC) with synergistically suppressing deposition of stone and bacteria, displaying a sustainable and effective anti-clogging capability. Taking infused ionic liquids (ILs) as the liquid barrier, the inhibition of stone deposition comes from reducing mineral nucleation and interfacial adhesion. Compared with traditional PVC, the BLBC shows excellent and universal anti-stone ability, displaying ca. 96.4 % reduction for CaCO<sub>3</sub> and ca. 96.2 % reduction for CaSO<sub>4</sub>. Because Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> always exists in the form of flocculent precipitation with low adhesion on most substrates, a high anti-stone result (ca. 44.5 % reduction) for Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> can be kept. Moreover, the experiments and DFT results reveal that enhancing IL-substrate affinity and attenuating IL dissolution endows the BLBCs with the sustainable stability of IL layer, and subsequent the durability of anti-stone and anti-bacteria. Compared with commercial urinary catheter, the BLBC extends anti-crystal biofilm from one to five days in vitro model of flow cells, displaying a significant reduction for two main clogging minerals (i.e., ca. 97.7 % for Mg(NH<sub>4</sub>)PO<sub>4</sub> and 89.9 % for Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub>). Therefore, this study may provide a promising tactic to avert the clogging problem of urinary catheter.</p></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":null,"pages":null},"PeriodicalIF":13.2000,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Today","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1748013224002688","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Catheter clogging by crystal biofilm always causes enormous economic burden and serious consequences. However, most researches mainly focus on anti-bacteria while neglecting the deposition of stone, which often protects encapsulated bacteria and accelerates catheter clogging. Inspired by Nepenthes pitcher, we herein present a bioinspired liquid barrier-infused coating (BLBC) with synergistically suppressing deposition of stone and bacteria, displaying a sustainable and effective anti-clogging capability. Taking infused ionic liquids (ILs) as the liquid barrier, the inhibition of stone deposition comes from reducing mineral nucleation and interfacial adhesion. Compared with traditional PVC, the BLBC shows excellent and universal anti-stone ability, displaying ca. 96.4 % reduction for CaCO3 and ca. 96.2 % reduction for CaSO4. Because Ca3(PO4)2 always exists in the form of flocculent precipitation with low adhesion on most substrates, a high anti-stone result (ca. 44.5 % reduction) for Ca3(PO4)2 can be kept. Moreover, the experiments and DFT results reveal that enhancing IL-substrate affinity and attenuating IL dissolution endows the BLBCs with the sustainable stability of IL layer, and subsequent the durability of anti-stone and anti-bacteria. Compared with commercial urinary catheter, the BLBC extends anti-crystal biofilm from one to five days in vitro model of flow cells, displaying a significant reduction for two main clogging minerals (i.e., ca. 97.7 % for Mg(NH4)PO4 and 89.9 % for Ca3(PO4)2). Therefore, this study may provide a promising tactic to avert the clogging problem of urinary catheter.
期刊介绍:
Nano Today is a journal dedicated to publishing influential and innovative work in the field of nanoscience and technology. It covers a wide range of subject areas including biomaterials, materials chemistry, materials science, chemistry, bioengineering, biochemistry, genetics and molecular biology, engineering, and nanotechnology. The journal considers articles that inform readers about the latest research, breakthroughs, and topical issues in these fields. It provides comprehensive coverage through a mixture of peer-reviewed articles, research news, and information on key developments. Nano Today is abstracted and indexed in Science Citation Index, Ei Compendex, Embase, Scopus, and INSPEC.