Constipation prevalence and risk from prescribed medications in people with intellectual disability: Findings from an English mortality programme.

IF 1.5 4区医学 Q2 EDUCATION, SPECIAL

Journal of Intellectual Disabilities Pub Date : 2024-07-19 DOI:10.1177/17446295241267085

Christina Roberts, Jonathon Ding, Delia Bishara, Sahar Riaz, Rory Sheehan, Adam White, Andre Strydom, Umesh Chauhan

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Abstract

Constipation is common in people with intellectual disability, with case reports of associated deaths. Risk factors include lifestyle factors, health conditions, and certain medications. We aimed to explore constipation in a sample of people with intellectual disability who died in 2021. We described prevalence of constipation, causes of death and the risk of secondary constipation from prescribed medications. Medications were scored based on the risk of constipation indicated in the drug profile. Forty-eight percent of the sample had constipation. Half of the sample were prescribed at least two medications that are commonly associated with side effects of constipation. There were high rates of antipsychotic (30%) and laxative (40%) drug prescription. Five people with a history of constipation died of causes of death associated with constipation. Our findings highlight the risk of secondary constipation due to prescribed medication and the seriousness of the condition in people with intellectual disability.

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智障人士便秘的发生率和处方药带来的风险：一项英国死亡率计划的研究结果。

便秘在智障人士中很常见，有相关死亡病例报告。风险因素包括生活方式因素、健康状况和某些药物。我们旨在对 2021 年死亡的智障人士样本中的便秘情况进行调查。我们描述了便秘的发病率、死亡原因以及处方药引起继发性便秘的风险。根据药物简介中显示的便秘风险对药物进行评分。48%的样本患有便秘。半数样本至少服用了两种通常与便秘副作用相关的药物。抗精神病药物（30%）和泻药（40%）的处方比例很高。五名有便秘病史的患者死于与便秘相关的死因。我们的研究结果突显了因处方药导致继发性便秘的风险，以及这种情况在智障人士中的严重性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Intellectual Disabilities Multiple-

CiteScore

3.40

自引率

13.30%

发文量

期刊介绍： The principal aim of the journal is to provide a medium for the exchange of best practice, knowledge and research between academic and professional disciplines from education, social and health settings to bring about advancement of services for people with intellectual disabilities. The idea of a practice-led journal is both exciting and timely. This journal serves as a medium for all those involved with people with intellectual disabilities to submit and publish papers on issues relevant to promoting services for people with intellectual disabilities.