LeishGEM: genome-wide deletion mutant fitness and protein localisations in Leishmania.

IF 7 1区医学 Q1 PARASITOLOGY

Trends in parasitology Pub Date : 2024-08-01 Epub Date: 2024-07-18 DOI:10.1016/j.pt.2024.06.003

引用次数: 0

Abstract

LeishGEM is a genome-wide functional annotation community resource for Leishmania mexicana, where deletion mutant growth in vitro and in vivo is measured and protein localisation is determined by endogenous tagging and LOPIT-DC (localisation of organelle proteins by isotope tagging with differential centrifugation) spatial proteomics. Data are being made available pre-publication via http://leishgem.org which allows data-driven identification of the mechanisms for Leishmania parasitism.

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LeishGEM：利什曼病全基因组缺失突变适配性和蛋白质定位。

LeishGEM 是一个针对墨西哥利什曼原虫的全基因组功能注释社区资源，该资源用于测量缺失突变体在体外和体内的生长情况，并通过内源标记和 LOPIT-DC（通过同位素标记和差速离心对细胞器蛋白质进行定位）空间蛋白质组学确定蛋白质的定位。数据可在发表前通过 http://leishgem.org 获取，从而以数据为导向确定利什曼原虫的寄生机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in parasitology 医学-寄生虫学

CiteScore

14.00

自引率

3.10%

发文量

148

审稿时长

6-12 weeks

期刊介绍： Since its inception as Parasitology Today in 1985, Trends in Parasitology has evolved into a highly esteemed review journal of global significance, reflecting the importance of medical and veterinary parasites worldwide. The journal serves as a hub for communication among researchers across all disciplines of parasitology, encompassing endoparasites, ectoparasites, transmission vectors, and susceptible hosts. Each monthly issue of Trends in Parasitology offers authoritative, cutting-edge, and yet accessible review articles, providing a balanced and comprehensive overview, along with opinion pieces offering personal and novel perspectives. Additionally, the journal publishes a variety of short articles designed to inform and stimulate thoughts in a lively and widely-accessible manner. These include Science & Society (discussing the interface between parasitology and the general public), Spotlight (highlighting recently published research articles), Forum (presenting single-point hypotheses), Parasite/Vector of the Month (featuring a modular display of the selected species), Letter (providing responses to recent articles in Trends in Parasitology), and Trendstalk (conducting interviews). Please note that the journal exclusively publishes literature reviews based on published data, with systematic reviews, meta-analysis, and unpublished primary research falling outside our scope.