The history of interferon-stimulated genes in pregnant cattle, sheep, and pigs.

IF 3.7 3区生物学 Q1 DEVELOPMENTAL BIOLOGY

Reproduction Pub Date : 2024-09-04 Print Date: 2024-10-01 DOI:10.1530/REP-24-0130

Gregory A Johnson, Fuller W Bazer, Robert C Burghardt, Heewon Seo, Guoyao Wu, Joe W Cain, Ky G Pohler

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引用次数: 0

Abstract

In brief: The trophectoderm of the elongating conceptuses of cattle, sheep, and pigs secrete high amounts of interferons that increase or induce the expression of interferon-stimulated genes (ISGs) in the endometrium. Research concerning ISGs, performed from 1995 through 2023, is reviewed in this manuscript.

Abstract: Expression of the classical interferon (IFN) stimulated genes (ISGs) increases in the endometrial stroma and glandular epithelium (GE) through activation of signal transducer and activator of transcription (STAT) signaling in response to the secretion of IFN tau (IFNT) and IFN gamma (IFNG) by the conceptuses of ruminants, including cattle and sheep, and pigs, respectively. The first of the classical ISGs to be characterized was ISG15 in cattle. Classical ISGs are not expressed by the endometrial luminal epithelium (LE) due to the expression of interferon regulatory factor 2 (IRF2) in the LE that prevents the expression of ISGs in the LE. Classical ISG expression in the endometrium serves as a reliable indicator of conceptus health and elongation in cattle. There are also nonclassical ISGs that are upregulated in endometrial LE in response to progesterone (P4) that are further stimulated by IFNT in sheep, the intracellular signaling pathway responsible for IFN effects on expression is unknown. ISGs are also upregulated in extrauterine tissues including CL and peripheral blood mononuclear cells (PBMCs). The expression of ISGs by the PBMCs of cattle serves as an early prognosticator of pregnancy. The physiological roles of ISGs remain obscure, but evidence suggests that they are at least in part involved in modifying the immune system to support endometrial remodeling necessary for the successful implantation of the conceptus. Our understanding of these ISGs is primarily the result of work from the laboratories of Drs Fuller Bazer, Thomas (Tod) Hansen, Gregory Johnson, Hakhyun Ka, Patrick Lonergan, Troy Ott, and Thomas Spencer.

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妊娠牛、绵羊和猪的干扰素刺激基因 (ISG) 的历史。

反刍动物（包括牛、羊和猪）的胚胎分别分泌 IFN tau (IFNT) 和 IFN gamma (IFNG)，通过激活信号转导和转录激活因子 (STAT) 信号，经典干扰素 (IFN) 刺激基因 (ISGs) 在子宫内膜基质和腺上皮 (GE) 中的表达增加。牛的 ISG15 是第一个被鉴定的经典 ISG。子宫内膜腔上皮（LE）不表达经典的 ISGs，这是因为 LE 中干扰素调节因子 2（IRF2）的表达阻止了 ISGs 在 LE 中的表达。子宫内膜中经典 ISG 的表达是牛孕囊健康和伸长的可靠指标。还有一些非典型 ISGs，它们在子宫内膜后叶对孕酮（P4）的反应中上调，并在绵羊的 IFNT 刺激下进一步上调，但 IFN 对表达产生影响的细胞内信号通路尚不清楚。ISGs在子宫外组织（包括CL和外周血单核细胞（PBMCs））中也会上调。牛的外周血单核细胞表达的 ISGs 可作为妊娠的早期预报因子。ISGs 的生理作用仍不明确，但有证据表明，它们至少部分参与了免疫系统的调节，以支持成功植入胚胎所需的子宫内膜重塑。我们对这些 ISGs 的了解主要来自 Fuller Bazer、Thomas (Tod) Hansen、Gregory Johnson、Hakhyun Ka、Patrick Lonergan、Troy Ott 和 Thomas Spencer 博士实验室的工作成果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproduction 生物-发育生物学

CiteScore

7.40

自引率

2.60%

发文量

199

审稿时长

4-8 weeks

期刊介绍： Reproduction is the official journal of the Society of Reproduction and Fertility (SRF). It was formed in 2001 when the Society merged its two journals, the Journal of Reproduction and Fertility and Reviews of Reproduction. Reproduction publishes original research articles and topical reviews on the subject of reproductive and developmental biology, and reproductive medicine. The journal will consider publication of high-quality meta-analyses; these should be submitted to the research papers category. The journal considers studies in humans and all animal species, and will publish clinical studies if they advance our understanding of the underlying causes and/or mechanisms of disease. Scientific excellence and broad interest to our readership are the most important criteria during the peer review process. The journal publishes articles that make a clear advance in the field, whether of mechanistic, descriptive or technical focus. Articles that substantiate new or controversial reports are welcomed if they are noteworthy and advance the field. Topics include, but are not limited to, reproductive immunology, reproductive toxicology, stem cells, environmental effects on reproductive potential and health (eg obesity), extracellular vesicles, fertility preservation and epigenetic effects on reproductive and developmental processes.