Global and regional mortality statistics of nipah virus from 1994 to 2023: a comprehensive systematic review and meta-analysis.

IF 4.9 4区 医学 Q1 PARASITOLOGY
Pathogens and Global Health Pub Date : 2024-09-01 Epub Date: 2024-07-20 DOI:10.1080/20477724.2024.2380131
Srivatsa Surya Vasudevan, Arun Subash, Fena Mehta, Tiba Yamin Kandrikar, Rupak Desai, Kaif Khan, Sneha Khanduja, Aakanksha Pitliya, Lekhya Raavi, Sai Gautham Kanagala, Piyush Gondaliya
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Abstract

The mortality rate of Nipah virus (NiV) can vary in different regions, and its pattern across timelines has yet to be assessed. The primary objective is to perform a comparative analysis of mortality rates across different timelines and countries. Articles reporting NiV mortality from inception to November 2023 were analyzed in PubMed, Ovid Embase, Scopus, and Web of Science databases. A meta-analysis utilizing random-effects models determined the mortality rate secondary to NiV complications. The initial search strategy yielded 1213 records, of which 36 articles met the inclusion criteria, comprising 2736 NiV patients. The Global mortality rate of the Nipah virus in the 2014-2023 decade was 80.1% (CI: 68.7-88.1%), indicating a significant 24% increase compared to the preceding decade (2004-2013) with a mortality rate of 54.1% (CI: 35.5-71.6%). Among the countries analyzed for overall mortality from 1994-2023, India experienced the highest mortality rate at 82.7% (CI: 74.6-88.6%), followed by Bangladesh at 62.1% (CI: 45.6-76.2%), Philippines at 52.9% (CI: 30-74.5%), Malaysia at 28.9% (CI: 21.4-37.9%), and Singapore at 21% (CI: 8-45%). Subgroup analysis revealed that India consistently had the highest mortality rate for the past two decades (91.7% and 89.3%). The primary complication leading to mortality was encephalitis, accounting for 95% of cases. This systematic review and meta-analysis revealed a noteworthy surge in NiV mortality rates, particularly in the current decade (2014-2023). The escalation, with India reporting a concerning level of mortality of 89.3-91.7% in the past decades, signifies a pressing public health challenge.

1994 年至 2023 年全球和地区尼帕病毒死亡率统计:全面系统回顾和荟萃分析。
尼帕病毒(NiV)的死亡率在不同地区会有所不同,其在不同时间段的模式也有待评估。本研究的主要目的是对不同时间段和不同国家的死亡率进行比较分析。我们在 PubMed、Ovid Embase、Scopus 和 Web of Science 数据库中分析了从开始到 2023 年 11 月期间报告 NiV 死亡率的文章。利用随机效应模型进行的荟萃分析确定了继发于NiV并发症的死亡率。最初的搜索策略产生了 1213 条记录,其中 36 篇文章符合纳入标准,包括 2736 名 NiV 患者。2014-2023年十年间,尼帕病毒的全球死亡率为80.1%(CI:68.7-88.1%),与前十年(2004-2013年)54.1%(CI:35.5-71.6%)的死亡率相比,显著增加了24%。在 1994-2023 年总体死亡率分析国家中,印度的死亡率最高,为 82.7%(CI:74.6-88.6%),其次是孟加拉国的 62.1%(CI:45.6-76.2%)、菲律宾的 52.9%(CI:30-74.5%)、马来西亚的 28.9%(CI:21.4-37.9%)和新加坡的 21%(CI:8-45%)。分组分析显示,在过去二十年中,印度的死亡率一直最高(91.7% 和 89.3%)。导致死亡的主要并发症是脑炎,占 95% 的病例。这项系统回顾和荟萃分析显示,尼罗河病毒死亡率显著上升,尤其是在当前十年(2014-2023 年)。在过去几十年中,印度报告的死亡率为 89.3%-91.7%,令人担忧。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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