A qualitative approach to assess the opinion of physicians about the challenges and prospects of pharmacogenomic testing implementation in clinical practice in Greece.

IF 3.8 3区 医学 Q2 GENETICS & HEREDITY
Margarita-Ioanna Koufaki, George P Patrinos, Konstantinos Z Vasileiou
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Abstract

Background: Pharmacogenomics (PGx) constitutes an important part of personalized medicine and has several clinical applications. PGx role in clinical practice is known, however, it has not been widely adopted yet. In this study, we aim to investigate the perspectives of Greek physicians regarding the implementation of PGx testing in clinical practice and the key issues associated with it.

Methods: Fourteen interviews were conducted with physicians of various specialties for which PGx applications are available. A semi-structured interview guide was utilized based on the Consolidated Framework for Implementation Research (CFIR) context and the Diffusion of Innovation model. Transcripts were coded independently and compared by two members of the research team. Descriptive statistics were generated using Microsoft Excel.

Results: Six main themes emerged: awareness and use of PGx testing; source of information; key stakeholders of the PGx supply chain, their interactions and change agents; clinical benefit and significance of PGx testing; barriers and lack of reimbursement; and recommendations to boost the PGx adoption rate. Most respondents were aware of PGx applications, but only three had already recommended PGx testing. Peer-reviewed journals along with clinical guidelines were regarded as the most used source of information while stakeholders of the PGx supply chain were discussed. PGx was considered that promote patient-centered care, enhance medication clinical effectiveness, decrease the risk of side effects, and reduce healthcare costs. Lack of reimbursement, scarcity of resources, and high PGx cost were the foremost barriers affecting PGx adoption.

Conclusions: It was concluded that if case PGx testing is reimbursed and physicians' training is reinforced, PGx implementation will be boosted and improved shortly.

采用定性方法评估医生对希腊临床实践中实施药物基因组测试的挑战和前景的看法。
背景:药物基因组学(PGx)是个性化医疗的重要组成部分,在临床上有多种应用。PGx 在临床实践中的作用众所周知,但尚未被广泛采用。在本研究中,我们旨在调查希腊医生对在临床实践中实施 PGx 检测的看法以及与之相关的关键问题:方法:我们对可应用 PGx 的各专科医师进行了 14 次访谈。根据实施研究综合框架 (CFIR) 和创新扩散模型,采用了半结构化访谈指南。研究小组的两名成员对访谈记录进行了独立编码和比较。使用 Microsoft Excel 生成描述性统计:出现了六大主题:对 PGx 检验的认识和使用;信息来源;PGx 供应链的主要利益相关者、他们之间的互动和变革推动者;PGx 检验的临床益处和意义;障碍和缺乏报销;以及提高 PGx 采用率的建议。大多数受访者都知道 PGx 的应用,但只有三个受访者已经推荐了 PGx 检测。同行评议期刊和临床指南被认为是最常用的信息来源,而 PGx 供应链的利益相关者也参与了讨论。PGx 被认为能促进以患者为中心的护理、提高药物临床疗效、降低副作用风险并降低医疗成本。缺乏补偿、资源稀缺和 PGx 成本高昂是影响 PGx 应用的主要障碍:结论:如果病例 PGx 检测能获得报销并加强对医生的培训,PGx 的实施将很快得到推动和改善。
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来源期刊
Human Genomics
Human Genomics GENETICS & HEREDITY-
CiteScore
6.00
自引率
2.20%
发文量
55
审稿时长
11 weeks
期刊介绍: Human Genomics is a peer-reviewed, open access, online journal that focuses on the application of genomic analysis in all aspects of human health and disease, as well as genomic analysis of drug efficacy and safety, and comparative genomics. Topics covered by the journal include, but are not limited to: pharmacogenomics, genome-wide association studies, genome-wide sequencing, exome sequencing, next-generation deep-sequencing, functional genomics, epigenomics, translational genomics, expression profiling, proteomics, bioinformatics, animal models, statistical genetics, genetic epidemiology, human population genetics and comparative genomics.
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