The complete genome of equid herpesvirus-1 (EHV-1) field isolates from Argentina reveals an interspecific recombinant strain.

IF 1.9 4区医学 Q3 GENETICS & HEREDITY

Virus Genes Pub Date : 2024-10-01 Epub Date: 2024-07-19 DOI:10.1007/s11262-024-02093-4

Rocio Lucia Tau, Ana Eugenia Marandino, Yanina Panzera, Florencia Alamos, Maria Aldana Vissani, Sonia Alejandra Romera, Ruben Pérez, Silvina Soledad Maidana

{"title":"The complete genome of equid herpesvirus-1 (EHV-1) field isolates from Argentina reveals an interspecific recombinant strain.","authors":"Rocio Lucia Tau, Ana Eugenia Marandino, Yanina Panzera, Florencia Alamos, Maria Aldana Vissani, Sonia Alejandra Romera, Ruben Pérez, Silvina Soledad Maidana","doi":"10.1007/s11262-024-02093-4","DOIUrl":null,"url":null,"abstract":"<p><p>The Equid alphaherpesvirus type 1 (EHV-1) infection can have devastating economic consequences in the horse industry due to large-scale outbreaks of abortions, perinatal foal mortality, and myeloencephalopathy. The present study analyzed the genome of two isolates obtained from aborted fetuses in Argentina, E/745/99 and E/1297/07. The E745/99 genome shares 98.2% sequence identity with Ab4, a reference EHV-1 strain. The E/1297/07 genome shares 99.8% identity with NY03, a recombinant strain containing part of ORF64 and part of the intergenic region from Equid alphaherpesvirus-4 (EHV-4). The E/1297/07 genome has the same breakpoints as other United States and Japanese recombinants, including NY03. The recombinant regions have varying numbers of tandem repeat sequences and different minor parental sequences (EHV-4), suggesting distinct origins of the recombinant events. These are the first complete genomes of EHV-1 from Argentina and South America available in the Databases.</p>","PeriodicalId":51212,"journal":{"name":"Virus Genes","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virus Genes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11262-024-02093-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}

引用次数: 0

Abstract

The Equid alphaherpesvirus type 1 (EHV-1) infection can have devastating economic consequences in the horse industry due to large-scale outbreaks of abortions, perinatal foal mortality, and myeloencephalopathy. The present study analyzed the genome of two isolates obtained from aborted fetuses in Argentina, E/745/99 and E/1297/07. The E745/99 genome shares 98.2% sequence identity with Ab4, a reference EHV-1 strain. The E/1297/07 genome shares 99.8% identity with NY03, a recombinant strain containing part of ORF64 and part of the intergenic region from Equid alphaherpesvirus-4 (EHV-4). The E/1297/07 genome has the same breakpoints as other United States and Japanese recombinants, including NY03. The recombinant regions have varying numbers of tandem repeat sequences and different minor parental sequences (EHV-4), suggesting distinct origins of the recombinant events. These are the first complete genomes of EHV-1 from Argentina and South America available in the Databases.

Abstract Image

查看原文本刊更多论文

阿根廷马疱疹病毒-1（EHV-1）野外分离株的完整基因组揭示了一个种间重组株。

马甲型疱疹病毒 1 型（EHV-1）感染会导致大规模的流产、围产期马驹死亡和髓脑病爆发，给养马业带来毁灭性的经济后果。本研究分析了从阿根廷流产胎儿中获得的两个分离株（E/745/99 和 E/1297/07）的基因组。E745/99 基因组与参考 EHV-1 株 Ab4 有 98.2% 的序列相同性。E/1297/07基因组与NY03有99.8%的同一性，NY03是一种重组毒株，含有ORF64的一部分和EHV-4（Equid alphaherpesvirus-4）基因间区的一部分。E/1297/07 基因组与包括 NY03 在内的其他美国和日本重组株具有相同的断裂点。重组区域具有不同数量的串联重复序列和不同的次要亲本序列（EHV-4），表明重组事件的起源不同。这些是数据库中首个来自阿根廷和南美洲的 EHV-1 完整基因组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Virus Genes 医学-病毒学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Viruses are convenient models for the elucidation of life processes. The study of viruses is again on the cutting edge of biological sciences: systems biology, genomics, proteomics, metagenomics, using the newest most powerful tools. Huge amounts of new details on virus interactions with the cell, other pathogens and the hosts – animal (including human), insect, fungal, plant, bacterial, and archaeal - and their role in infection and disease are forthcoming in perplexing details requiring analysis and comments. Virus Genes is dedicated to the publication of studies on the structure and function of viruses and their genes, the molecular and systems interactions with the host and all applications derived thereof, providing a forum for the analysis of data and discussion of its implications, and the development of new hypotheses.