Performance of ACR-TIRADS in assessing thyroid nodules does not vary according to patient age.

IF 2.4 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Hormones-International Journal of Endocrinology and Metabolism Pub Date : 2024-12-01 Epub Date: 2024-07-19 DOI:10.1007/s42000-024-00585-4

Andrea Leoncini, Marco Curti, Lorenzo Ruinelli, Elena Gamarra, Pierpaolo Trimboli

{"title":"Performance of ACR-TIRADS in assessing thyroid nodules does not vary according to patient age.","authors":"Andrea Leoncini, Marco Curti, Lorenzo Ruinelli, Elena Gamarra, Pierpaolo Trimboli","doi":"10.1007/s42000-024-00585-4","DOIUrl":null,"url":null,"abstract":"Aims: A few studies have evaluated the performance of the American College of Radiology Thyroid Imaging Reporting And Data System (ACR-TIRADS) in pediatric and elderly patients and found differences between the latter two age groups and middle adulthood. Thus, the present study was undertaken to explore the possible variation of ACR-TIRADS performance across different ages of patients.Methods: A retrospective population undergoing thyroidectomy was selected to use histology as the reference standard. Ultrasound images were reviewed, and alignment of ACR-TIRADS with the corresponding histological diagnosis was made afterwards. Results of the age groups were compared. The ACR-TIRADS diagnostic performance was calculated considering the assessment of nodules across risk categories (i.e., from TR1 to TR5), rate of unnecessary FNAC (UN-FNAC), and rate of necessary but non-performed FNAC (NNP-FNAC).Results: Overall, 114 patients with a total of 220 nodules (46 carcinomas) were included. The rate of UN-FNAC was 66.3%, being 93.1% in TR3, 82.1% in TR4, and 31.4% in TR5. There were 15 NNP-FNACs. No significant difference was observed between age groups in terms of sample size, nodule, cancer, and FNAC. The nodule assessment according to ACR-TIRADS categories did not vary across ages. Sensitivity and specificity recorded in three age tertiles were not significantly different.Conclusions: The present study shows that the performance of ACR-TIRADS is not significantly influenced by patient age.","PeriodicalId":50399,"journal":{"name":"Hormones-International Journal of Endocrinology and Metabolism","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519249/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hormones-International Journal of Endocrinology and Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s42000-024-00585-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/7/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Aims: A few studies have evaluated the performance of the American College of Radiology Thyroid Imaging Reporting And Data System (ACR-TIRADS) in pediatric and elderly patients and found differences between the latter two age groups and middle adulthood. Thus, the present study was undertaken to explore the possible variation of ACR-TIRADS performance across different ages of patients.

Methods: A retrospective population undergoing thyroidectomy was selected to use histology as the reference standard. Ultrasound images were reviewed, and alignment of ACR-TIRADS with the corresponding histological diagnosis was made afterwards. Results of the age groups were compared. The ACR-TIRADS diagnostic performance was calculated considering the assessment of nodules across risk categories (i.e., from TR1 to TR5), rate of unnecessary FNAC (UN-FNAC), and rate of necessary but non-performed FNAC (NNP-FNAC).

Results: Overall, 114 patients with a total of 220 nodules (46 carcinomas) were included. The rate of UN-FNAC was 66.3%, being 93.1% in TR3, 82.1% in TR4, and 31.4% in TR5. There were 15 NNP-FNACs. No significant difference was observed between age groups in terms of sample size, nodule, cancer, and FNAC. The nodule assessment according to ACR-TIRADS categories did not vary across ages. Sensitivity and specificity recorded in three age tertiles were not significantly different.

Conclusions: The present study shows that the performance of ACR-TIRADS is not significantly influenced by patient age.

Abstract Image

查看原文本刊更多论文

ACR-TIRADS 在评估甲状腺结节方面的性能并不因患者年龄而异。

目的：有几项研究评估了美国放射学会甲状腺成像报告和数据系统（ACR-TIRADS）在儿童和老年患者中的表现，发现后两个年龄组与中年人之间存在差异。因此，本研究旨在探讨 ACR-TIRADS 在不同年龄段患者中的表现可能存在的差异：方法：选择接受甲状腺切除术的回顾性人群，以组织学作为参考标准。方法：选取接受甲状腺切除术的回顾性人群，以组织学作为参考标准，对超声图像进行审查，之后将 ACR-TIRADS 与相应的组织学诊断进行比对。对各年龄组的结果进行比较。考虑到不同风险类别（即从 TR1 到 TR5）的结节评估、不必要的 FNAC 率（UN-FNAC）和必要但未进行的 FNAC 率（NNP-FNAC），计算了 ACR-TIRADS 诊断性能：结果：共纳入了 114 名患者的 220 个结节（46 个癌瘤）。UN-FNAC 的比例为 66.3%，其中 TR3 为 93.1%，TR4 为 82.1%，TR5 为 31.4%。NNP-FNAC为15例。各年龄组在样本量、结节、癌症和 FNAC 方面均无明显差异。根据 ACR-TIRADS 分类进行的结节评估在不同年龄段之间没有差异。三个年龄组的敏感性和特异性无明显差异：本研究表明，ACR-TIRADS 的性能不受患者年龄的明显影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Hormones-International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hormones-International Journal of Endocrinology and Metabolism is an international journal published quarterly with an international editorial board aiming at providing a forum covering all fields of endocrinology and metabolic disorders such as disruption of glucose homeostasis (diabetes mellitus), impaired homeostasis of plasma lipids (dyslipidemia), the disorder of bone metabolism (osteoporosis), disturbances of endocrine function and reproductive capacity of women and men. Hormones-International Journal of Endocrinology and Metabolism particularly encourages clinical, translational and basic science submissions in the areas of endocrine cancers, nutrition, obesity and metabolic disorders, quality of life of endocrine diseases, epidemiology of endocrine and metabolic disorders.