Maternal-Fetal Microchimerism: Impacts on Offspring's Immune Development and Transgenerational Immune Memory Transfer.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-17 DOI:10.33549/physiolres.935296

N Malinská, V Grobárová, K Knížková, J Černý

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Abstract

Maternal-fetal microchimerism is a fascinating phenomenon in which maternal cells migrate to the tissues of the offspring during both pregnancy and breastfeeding. These cells primarily consist of leukocytes and stem cells. Remarkably, these maternal cells possess functional potential in the offspring and play a significant role in shaping their immune system development. T lymphocytes, a cell population mainly found in various tissues of the offspring, have been identified as the major cell type derived from maternal microchimerism. These T lymphocytes not only exert effector functions but also influence the development of the offspring's T lymphocytes in the thymus and the maturation of B lymphocytes in the lymph nodes. Furthermore, the migration of maternal leukocytes also facilitates the transfer of immune memory across generations. Maternal microchimerism has also been observed to address immunodeficiencies in the offspring. This review article focuses on investigating the impact of maternal cells transported within maternal microchimerism on the immune system development of the offspring, as well as elucidating the effector functions of maternal cells that migrate through the placenta and breast milk to reach the offspring.

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母胎微嵌合体：对后代免疫发育和跨代免疫记忆转移的影响

母胎微嵌合体现象是一种令人着迷的现象，即母体细胞在怀孕和哺乳期间迁移到后代的组织中。这些细胞主要由白细胞和干细胞组成。值得注意的是，这些母体细胞在后代体内具有功能潜能，并在塑造后代免疫系统发育过程中发挥着重要作用。T 淋巴细胞是主要存在于后代各种组织中的细胞群，已被确认为母体微嵌合体衍生的主要细胞类型。这些 T 淋巴细胞不仅具有效应功能，还影响后代胸腺中 T 淋巴细胞的发育和淋巴结中 B 淋巴细胞的成熟。此外，母体白细胞的迁移还有助于免疫记忆的跨代传递。还观察到母体微嵌合体可解决后代的免疫缺陷问题。这篇综述文章的重点是研究母体微嵌合体内运输的母体细胞对后代免疫系统发育的影响，以及阐明通过胎盘和母乳迁移到后代体内的母体细胞的效应功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.