The effect of heart rate variability on the choroidal vascularity of the optical coherence tomography and angiography in central serous chorioretinopathy.

IF 2.4 3区 医学 Q2 OPHTHALMOLOGY
Bo-Een Hwang, Joo-Young Kim, Young-Hoon Park
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引用次数: 0

Abstract

Purpose: To investigate the correlation between the autonomic nervous system and choroidal vascularity in patients with central serous chorioretinopathy (CSC), using heart rate variability (HRV) analysis, optical coherence tomography (OCT) and OCT angiography (OCTA).

Methods: We retrospectively analyzed data of 25 patients with unilateral CSC (50 eyes, including the unaffected fellow eyes) and 25 healthy controls. The assessment involved a 5-minute HRV analysis encompassing both frequency and time domains, especially low frequency (LF), high frequency (HF), and LF/HF ratio. In OCT (12 × 9 mm) and en-face OCTA (3 × 3 mm) scans, we measured parameters including choroidal vascularity index (CVI), choroidal vessel density in the middle and deep layers, and choriocapillaris flow void. Regression analysis was conducted to elucidate the associations between HRV parameters and OCT/OCTA measurements.

Results: Normalized LF(LFnorm) and LF/HF ratios were higher in patients with CSC than in healthy controls. LFnorm and the log-transformed ratio of LF to HF [log(LF/HF)] demonstrated a significant and borderline correlation with CVI in the linear regression analysis (P = 0.040, R2 = 0.171, and P = 0.059, R2 = 0.147, respectively). Both CVI and deep choroid vessel density showed a more significant association with LFnorm and log (LF/HF) in the non-linear quadratic regression analysis than in the linear analysis (all, P < 0.04, R2 > 0.25).

Conclusion: The frequency-domain parameters of HRV, including LFnorm and log (LF/HF), demonstrated a significant association with indicators reflective of large choroidal vessel luminal area on macular OCT/OCTA scans. This observation implies complicated modulation of choroidal blood flow by the autonomic nervous system in CSC.

Abstract Image

心率变异性对中心性浆液性脉络膜视网膜病变的光学相干断层扫描和血管造影中脉络膜血管的影响。
目的:通过心率变异性(HRV)分析、光学相干断层扫描(OCT)和OCT血管造影(OCTA),研究中枢性浆液性脉络膜视网膜病变(CSC)患者的自主神经系统与脉络膜血管之间的相关性:我们对 25 名单侧 CSC 患者(50 只眼睛,包括未受影响的同侧眼睛)和 25 名健康对照者的数据进行了回顾性分析。评估包括 5 分钟的心率变异分析,包括频域和时域,尤其是低频(LF)、高频(HF)和 LF/HF 比值。在 OCT(12 × 9 毫米)和面内 OCTA(3 × 3 毫米)扫描中,我们测量了包括脉络膜血管指数(CVI)、中层和深层脉络膜血管密度以及脉络膜毛细血管流动空隙在内的参数。我们进行了回归分析,以阐明心率变异参数与 OCT/OCTA 测量值之间的关联:结果:与健康对照组相比,CSC 患者的归一化 LF(LFnorm)和 LF/HF 比值更高。在线性回归分析中,LFnorm 和 LF 与 HF 的对数转换比率[log(LF/HF)]与 CVI 存在显著的边缘相关性(分别为 P = 0.040,R2 = 0.171 和 P = 0.059,R2 = 0.147)。在非线性二次回归分析中,CVI 和脉络膜深层血管密度与 LFnorm 和 log (LF/HF) 的关系比线性分析更显著(均为 P 2 > 0.25):心率变异的频域参数(包括 LFnorm 和 log (LF/HF))与黄斑 OCT/OCTA 扫描中反映脉络膜大血管管腔面积的指标有显著关联。这一观察结果表明,CSC 患者的自主神经系统对脉络膜血流的调节十分复杂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.40
自引率
7.40%
发文量
398
审稿时长
3 months
期刊介绍: Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.
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