Association of late-life blood pressure change with cerebral small vessel disease in the MIND-China study.

IF 2.8 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2024-07-18 DOI:10.1186/s40001-024-01953-x

Wei Lu, Qingping Ma, Jiafeng Wang, Chunyan Li, Qianqian Xie, Ziwei Chen, Huisi Zhang, Lin Song, Yifeng Du

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引用次数: 0

Abstract

Objectives: This study aimed to investigate the associations between changes in blood pressure (BP) and cerebral small vessel disease (CSVD).

Methods: This study included 401 participants in the magnetic resonance imaging (MRI) sub-study conducted between 2018 and 2020 as a part of the Multidomain Interventions to Delay Dementia and Disability in Rural China project. MRI markers of CSVD were assessed based on international criteria. Individualized linear regression models evaluated changes in BP by estimating the trend of blood pressure changes over time and fitting a straight line from 2014 to 2018. The data were analyzed using logistic and general linear regression models.

Result: The mean age of the participants was 64.48 ± 2.69 years, with 237 (59.1%) being females. Increases in systolic BP in later life were significantly associated with larger volumes of periventricular white matter hyperintensity (WMH), greater perivascular spaces in the basal ganglia (BG-PVS) burden, and the presence of deep lacunes and cerebral microbleeds. Additionally, increases in diastolic BP in later life were significantly associated with the presence of infratentorial and deep lacunes.

Conclusions: CSVDs are associated with increased exposure to elevated BP later in life.

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中国 MIND 研究中晚年血压变化与脑小血管疾病的关系。

研究目的本研究旨在探讨血压（BP）变化与脑小血管疾病（CSVD）之间的关联：本研究纳入了2018年至2020年期间开展的磁共振成像（MRI）子研究的401名参与者，该子研究是 "中国农村延迟痴呆和残疾多领域干预项目 "的一部分。根据国际标准对CSVD的MRI标志物进行了评估。个体化线性回归模型通过估计血压随时间变化的趋势并拟合一条从2014年到2018年的直线来评估血压的变化。数据采用逻辑和一般线性回归模型进行分析：参与者的平均年龄为（64.48 ± 2.69）岁，其中女性 237 人（59.1%）。晚年收缩压的升高与脑室周围白质高密度（WMH）体积增大、基底节血管周围空间（BG-PVS）负荷增大、深裂隙和脑微出血的存在明显相关。此外，晚年舒张压的升高与视网膜下和深部脑裂的存在有显著关联：结论：慢性心血管疾病与晚年血压升高有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.