Risk of Malignancy in Effusions according to the International System for Serous Fluid Cytopathology: A Review.

IF 1.6 4区医学 Q3 PATHOLOGY

Acta Cytologica Pub Date : 2024-01-01 Epub Date: 2024-07-18 DOI:10.1159/000540414

Daniel José Castilho da Silva, Caio Rodrigo Dos Santos, José Cândido Caldeira Xavier-Júnior

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引用次数: 0

Abstract

Introduction: The International Serous Fluid Cytopathology Reporting System (TIS) was developed to standardize communication among health professionals reporting analyses of serous fluid samples. The categories include non-diagnosis (ND), negative for malignancy (NFM), atypia of undetermined significance (AUS), suspected malignancy (SFM), and malignant (MAL). Each category was characterized by a risk of malignancy (ROM).

Methods: We performed a literature review to analyze studies related to TIS using several sources, including PubMed, followed by a search of relevant cytopathology journal websites (American Cancer Society, Diagnostic Cytopathology, Journal of the American Society of Cytopathology, and Acta Cytologica and Cytopathology). The search included articles published between January 2020 and December 2023, using the terms "international AND serous fluid system."

Results: We identified 257 articles, of which 20 addressed the inclusion and exclusion criteria. The overall ROMs for each category were 23.55% for ND, 16.46% for NFM, 50.78% for AUS, 91.34% for SFM, and 98.21% for MAL.

Conclusion: Considering the TIS-recommended ROM rates, the ND category was between the suggested intervals, while the SFM category rate was bigger than expected. The other categories (NFM, AUS, and MAL) were below expected values. SFM and MAL had a stronger association with MAL results. New studies are needed to determine each category's ROM rate from TIS accurately.

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根据国际浆液细胞病理学系统得出的积液恶变风险：综述。

国际浆液细胞病理学报告系统（TIS）的开发旨在规范报告浆液样本分析结果的医疗专业人员之间的交流。其类别包括未诊断（ND）、恶性阴性（NFM）、意义未定的非典型（AUS）、疑似恶性（SFM）和恶性（MAL）。每个类别都有一个恶性风险（ROM）。我们进行了一次文献综述，利用包括PubMed在内的多个来源分析了与TIS相关的研究，随后又搜索了相关的细胞病理学期刊网站（美国癌症协会、《诊断细胞病理学》、《美国细胞病理学协会期刊》以及《细胞学与细胞病理学》）。检索包括 2020 年 1 月至 2023 年 12 月间发表的文章，检索词为 "国际和浆液系统"。我们确定了 257 篇文章，其中 20 篇符合纳入和排除标准。每个类别的总ROM分别为：ND为23.55%、NFM为16.46%、AUS为50.78%、SFM为91.34%、MAL为98.21%。考虑到 TIS 建议的 ROM 比率，ND 类别的比率介于建议的区间之间，而 SFM 类别的比率大于预期。其他类别（NFM、AUS 和 MAL）低于预期值。SFM和MAL与恶性结果的关联性更强。要从 TIS 中准确确定每个类别的 ROM 率，还需要进行新的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Cytologica 生物-病理学

CiteScore

3.70

自引率

11.10%

发文量

审稿时长

4-8 weeks

期刊介绍： With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.