Endocrine fibroblast growth factors in domestic animals

IF 1.9 2区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Domestic animal endocrinology Pub Date : 2024-07-09 DOI:10.1016/j.domaniend.2024.106872

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引用次数: 0

Abstract

Fibroblast growth factors (FGFs) are a group of structurally homologous yet functionally pleiotropic proteins. Canonical and intracellular FGFs have primarily autocrine or paracrine effects. However, the FGF19 subfamily, composed of FGF15/19, FGF21, and FGF23, act as endocrine hormones that regulate bile acid, metabolic, and phosphorus homeostasis, respectively. Current research in human and rodent models demonstrates the potential of these endocrine FGFs to target various diseases, including disorders of inherited hypophosphatemia, chronic liver disease, obesity, and insulin resistance. Many diseases targeted for therapeutic use in humans have pathophysiological overlaps in domestic animals. Despite the potential clinical and economic impact, little is known about endocrine FGFs and their signaling pathways in major domestic animal species compared with humans and laboratory animals. This review aims to describe the physiology of these endocrine FGFs, discuss their current therapeutic use, and summarize the contemporary literature regarding endocrine FGFs in domestic animals, focusing on potential future directions.

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家畜的内分泌成纤维细胞生长因子

成纤维细胞生长因子（FGFs）是一组结构同源但功能多样的蛋白质。典型的细胞内 FGFs 主要具有自分泌或旁分泌效应。然而，由 FGF15/19、FGF21 和 FGF23 组成的 FGF19 亚家族可作为内分泌激素，分别调节胆汁酸、代谢和磷平衡。目前在人类和啮齿类动物模型中进行的研究表明，这些内分泌 FGFs 具有治疗各种疾病的潜力，包括遗传性低磷血症、慢性肝病、肥胖和胰岛素抵抗等疾病。许多人类的治疗目标疾病在家畜身上都有病理生理学重叠。尽管存在潜在的临床和经济影响，但与人类和实验室动物相比，人们对主要家畜物种的内分泌成纤维细胞及其信号通路知之甚少。本综述旨在描述这些内分泌成纤维细胞生长因子的生理学，讨论其当前的治疗用途，并总结有关家畜内分泌成纤维细胞生长因子的当代文献，重点关注潜在的未来发展方向。

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来源期刊

Domestic animal endocrinology 农林科学-奶制品与动物科学

CiteScore

5.50

自引率

4.80%

发文量

审稿时长

31 days

期刊介绍： Domestic Animal Endocrinology publishes scientific papers dealing with the study of the endocrine physiology of domestic animal species. Those manuscripts utilizing other species as models for clinical or production problems associated with domestic animals are also welcome. Topics covered include: Classical and reproductive endocrinology- Clinical and applied endocrinology- Regulation of hormone secretion- Hormone action- Molecular biology- Cytokines- Growth factors