The national burden of mortality and its associated factors among burn patients in Ethiopia. A systematic review and meta-analysis

IF 3.2 3区医学 Q2 CRITICAL CARE MEDICINE

Burns Pub Date : 2024-12-01 DOI:10.1016/j.burns.2024.07.005

Mengistu Abebe Messelu , Nega Nigussie Abrha , Haymanot Kitaw Jemberie , Tiruye Azene Demile , Asnake Gashaw Belayneh

{"title":"The national burden of mortality and its associated factors among burn patients in Ethiopia. A systematic review and meta-analysis","authors":"Mengistu Abebe Messelu , Nega Nigussie Abrha , Haymanot Kitaw Jemberie , Tiruye Azene Demile , Asnake Gashaw Belayneh","doi":"10.1016/j.burns.2024.07.005","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Despite all advances in burn prevention, treatment, acute care, and rehabilitation, burn injuries continue to cause significant mortality and disability in Ethiopia. Thus, this review and meta-analysis aimed to assess the pooled prevalence and the determinants of mortality in Ethiopia.</div></div><div><h3>Methods</h3><div>This systematic review was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A structured search of databases (Medline/PubMed, Google Scholar, CINAHL, EMBASE, HINARI, and Web of Science) was undertaken. Selection, screening, reviewing, and data extraction were done by independent reviewers using a Microsoft Excel spreadsheet. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal tool. A random-effects meta-analysis model with a 95 % confidence interval was computed to estimate the pooled effect size (i.e., prevalence and odds ratio). Publication bias was checked using the funnel plot, Egger’s, and Begg’s tests. The heterogeneity of studies was assessed using I<sup>2</sup> statistics. Subgroup analysis based on the region and age group was done.</div></div><div><h3>Results</h3><div>This systematic review and meta-analysis included a total of ten studies. The pooled prevalence of mortality among patients with burn injuries in Ethiopia was found to be 6.01 % (95 % CI: 2.75, 9.26). Subgroup analysis based on the region showed that the pooled prevalence of mortality was highest in the Oromia region (12.02 %), followed by the Amhara region (8.5 %). Additionally, subgroup analysis based on patients’ ages revealed that the pooled estimates of mortality among all age groups and children were 5.18 % and 7.91 %, respectively. The meta-analysis demonstrated that the extent of burn > 10 % TBSA (OR = 5.04, 95 % CI: 2.72, 9.35), presence of comorbidity (OR = 4.01, 95 % CI: 1.44, 11.18), and presence of a 3rd degree burn (OR = 10.64, 95 % CI: 2.82, 40.16) were significantly associated with mortality among burn patients.</div></div><div><h3>Conclusion and recommendations</h3><div>The national prevalence of mortality among burn patients in Ethiopia was high. The extent of burn, presence of comorbidity, and 3rd degree burns were significant predictors of mortality. We strongly recommend that health care workers give special attention to burn patients with greater extent and depth of burn, and for those who have comorbid diseases.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"50 9","pages":"Article 107201"},"PeriodicalIF":3.2000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Burns","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0305417924002018","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CRITICAL CARE MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Despite all advances in burn prevention, treatment, acute care, and rehabilitation, burn injuries continue to cause significant mortality and disability in Ethiopia. Thus, this review and meta-analysis aimed to assess the pooled prevalence and the determinants of mortality in Ethiopia.

Methods

This systematic review was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). A structured search of databases (Medline/PubMed, Google Scholar, CINAHL, EMBASE, HINARI, and Web of Science) was undertaken. Selection, screening, reviewing, and data extraction were done by independent reviewers using a Microsoft Excel spreadsheet. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal tool. A random-effects meta-analysis model with a 95 % confidence interval was computed to estimate the pooled effect size (i.e., prevalence and odds ratio). Publication bias was checked using the funnel plot, Egger’s, and Begg’s tests. The heterogeneity of studies was assessed using I² statistics. Subgroup analysis based on the region and age group was done.

Results

This systematic review and meta-analysis included a total of ten studies. The pooled prevalence of mortality among patients with burn injuries in Ethiopia was found to be 6.01 % (95 % CI: 2.75, 9.26). Subgroup analysis based on the region showed that the pooled prevalence of mortality was highest in the Oromia region (12.02 %), followed by the Amhara region (8.5 %). Additionally, subgroup analysis based on patients’ ages revealed that the pooled estimates of mortality among all age groups and children were 5.18 % and 7.91 %, respectively. The meta-analysis demonstrated that the extent of burn > 10 % TBSA (OR = 5.04, 95 % CI: 2.72, 9.35), presence of comorbidity (OR = 4.01, 95 % CI: 1.44, 11.18), and presence of a 3rd degree burn (OR = 10.64, 95 % CI: 2.82, 40.16) were significantly associated with mortality among burn patients.

Conclusion and recommendations

The national prevalence of mortality among burn patients in Ethiopia was high. The extent of burn, presence of comorbidity, and 3rd degree burns were significant predictors of mortality. We strongly recommend that health care workers give special attention to burn patients with greater extent and depth of burn, and for those who have comorbid diseases.

查看原文本刊更多论文

埃塞俄比亚全国烧伤患者的死亡负担及其相关因素。系统回顾和荟萃分析

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Burns 医学-皮肤病学

CiteScore

4.50

自引率

18.50%

发文量

304

审稿时长

72 days

期刊介绍： Burns aims to foster the exchange of information among all engaged in preventing and treating the effects of burns. The journal focuses on clinical, scientific and social aspects of these injuries and covers the prevention of the injury, the epidemiology of such injuries and all aspects of treatment including development of new techniques and technologies and verification of existing ones. Regular features include clinical and scientific papers, state of the art reviews and descriptions of burn-care in practice. Topics covered by Burns include: the effects of smoke on man and animals, their tissues and cells; the responses to and treatment of patients and animals with chemical injuries to the skin; the biological and clinical effects of cold injuries; surgical techniques which are, or may be relevant to the treatment of burned patients during the acute or reconstructive phase following injury; well controlled laboratory studies of the effectiveness of anti-microbial agents on infection and new materials on scarring and healing; inflammatory responses to injury, effectiveness of related agents and other compounds used to modify the physiological and cellular responses to the injury; experimental studies of burns and the outcome of burn wound healing; regenerative medicine concerning the skin.