Etiopathogenesis of Acne Vulgaris

Abstract

Objectives: Describe examine the function of sebaceous glands in the development and progression of acne vulgaris and talk about its causes and prevalence. Acne, which often affects the face, upper chest, and back, is a condition that typically manifests in children and teenagers and is associated with an overproduction of the male hormone androgen by the sebaceous glands and the adrenal glands. Where the Data Came from: Finding research that explain the pathophysiology, etiology, and prevalence of acne vulgaris as well as the function of sebaceous glands up to the year 2024 was the goal of this search and study of Medline databases (Pub Med and Medscape). Research Question Selection: For inclusion, each study underwent an independent evaluation. They were considered for inclusion if they met the following requirements: 1. The text was written and published in English. 2. Bound in scholarly publications that undergo a rigorous peer review process.3. Discuss the function of sebaceous glands in the prevalence of acne vulgaris and describe its causes and pathophysiology. When extracting data, studies were discarded if they did not meet the inclusion criteria. Ethical permission, established eligibility criteria, sufficient information, and well-defined evaluation metrics were all variables in determining the study's quality. For our concerned research outcomes, data were independently extracted from all qualifying studies utilizing a data collecting form. In conclusion, stress, oxidative stress, hormones, obesity, and other variables are all contributors to the pathophysiology of acne and, by extension, the incidence of AV. There are four main elements that contribute to the pathogenesis process: inflammation, follicular hyperkeratosis (changes in follicular development and differentiation), seborrhea (increased sebum production), and the colonization of pilosebaceous units by C. acnes.