Changes in cortisol, cortisone and 11β-hydroxysteroid dehydrogenase type II activity in saliva during pregnancy and lactation in sows

IF 1.9 2区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Domestic animal endocrinology Pub Date : 2024-07-16 DOI:10.1016/j.domaniend.2024.106875

M. Botía , D. Escribano , F. Tecles , S. Martínez-Subiela , J.J. Cerón , M. López-Arjona

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Abstract

The activity of the enzyme 11β-hydroxysteroid dehydrogenase type II, which can be estimated by the combined measurement of cortisol and cortisone, is gaining importance as a marker for the assessment of stress in pigs. The aim of this study was to investigate the activity of this enzyme and the salivary concentrations of cortisol and cortisone in pigs during pregnancy, farrowing and lactation and to compare it with other stress-related biomarkers such as CgA, S100A12 and alpha-amylase. Salivary cortisol concentrations and 11β-hydroxysteroid dehydrogenase isoenzyme type 2 activity decreased after farrowing, while cortisol concentrations increased. Enzyme activity did not show significant correlations with any of the other stress-related biomarkers measured in this study. Overall, the results of this report indicate a different regulation of 11β-HSD type II activity and of cortisol and cortisone during pregnancy and lactation, which should be considered when evaluating these analytes in saliva during these periods.

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母猪妊娠期和哺乳期唾液中皮质醇、可的松和 11β- 羟基类固醇脱氢酶 II 型活性的变化

11β- 羟基类固醇脱氢酶 II 型的活性可通过联合测量皮质醇和可的松来估算，它作为评估猪应激的标志物正变得越来越重要。本研究旨在调查猪在妊娠、分娩和哺乳期间唾液中这种酶的活性以及皮质醇和可的松的浓度，并将其与其他与应激相关的生物标志物（如 CgA、S100A12 和 α-淀粉酶）进行比较。分娩后，唾液皮质醇浓度和 11β- 羟基类固醇脱氢酶 2 型同工酶活性下降，而皮质醇浓度上升。酶活性与本研究测量的其他应激相关生物标志物之间没有明显的相关性。总之，本报告的结果表明，11β-HSD II 型活性以及皮质醇和可的松在妊娠期和哺乳期有不同的调节作用，在这两个时期评估唾液中的这些分析物时应考虑到这一点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Domestic animal endocrinology 农林科学-奶制品与动物科学

CiteScore

5.50

自引率

4.80%

发文量

审稿时长

31 days

期刊介绍： Domestic Animal Endocrinology publishes scientific papers dealing with the study of the endocrine physiology of domestic animal species. Those manuscripts utilizing other species as models for clinical or production problems associated with domestic animals are also welcome. Topics covered include: Classical and reproductive endocrinology- Clinical and applied endocrinology- Regulation of hormone secretion- Hormone action- Molecular biology- Cytokines- Growth factors