Unveiling the effect of paper matrix on the electrochemical response of diffusive redox probes

IF 6.5 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Sensors and Actuators Reports Pub Date : 2024-07-16 DOI:10.1016/j.snr.2024.100224

Dmitry Galyamin , Eduardo Laborda , Juan Pablo Esquivel , Joaquín González , Neus Sabaté

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引用次数: 0

Abstract

This study evaluates the influence of paper substrate selection on the electrochemical response of an electrochemical paper-based analytical device (ePAD). Various paper substrates commonly employed in this type of devices such as cellulose, nitrocellulose and glass-fibre based medical grade materials are evaluated using chronoamperometric measurements. Both theoretical modelling and experimental analyses are conducted to understand the diffusion behaviour of widely employed two redox probes, [Fe(CN)₆]³⁻ and FcMeOH. Findings show that glass fibre substrates show similar performance to liquid drop conditions while nitrocellulose cause a decrease in current after a short measurement period, mainly due to a thin-layer effect. Cellulose-based substrates decrease the diffusivity of redox species, especially for charged species, indicating potential limitations in their use for chronoamperometric measurements. The study offers valuable insights into the electrochemical behaviour of paper substrates in ePADs, laying the groundwork for future research in this area.

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揭示纸基质对扩散氧化还原探针电化学响应的影响

本研究评估了纸基材选择对电化学纸基分析装置（ePAD）电化学响应的影响。研究使用计时电流测量法评估了此类设备中常用的各种纸张基底，如纤维素、硝化纤维素和玻璃纤维医用材料。通过理论建模和实验分析，了解了广泛使用的两种氧化还原探针 [Fe(CN)6]3- 和 FcMeOH 的扩散行为。研究结果表明，玻璃纤维基底的性能与液滴条件相似，而硝酸纤维素在短时间测量后会导致电流下降，这主要是由于薄层效应造成的。纤维素基底会降低氧化还原物种的扩散性，尤其是带电物种的扩散性，这表明纤维素基底在用于精密计时器测量方面存在潜在的局限性。这项研究为了解 ePAD 中纸基底的电化学行为提供了宝贵的见解，为该领域的未来研究奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sensors and Actuators Reports Multiple-

CiteScore

9.60

自引率

0.00%

发文量

审稿时长

49 days

期刊介绍： Sensors and Actuators Reports is a peer-reviewed open access journal launched out from the Sensors and Actuators journal family. Sensors and Actuators Reports is dedicated to publishing new and original works in the field of all type of sensors and actuators, including bio-, chemical-, physical-, and nano- sensors and actuators, which demonstrates significant progress beyond the current state of the art. The journal regularly publishes original research papers, reviews, and short communications. For research papers and short communications, the journal aims to publish the new and original work supported by experimental results and as such purely theoretical works are not accepted.