Soft coral Lobophytum crassum extract inhibits migration and induces apoptosis capabilities in human oral squamous cell carcinoma cells

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2025-01-01 DOI:10.1016/j.jds.2024.06.016

Shih-Min Wang , Mei-Chin Lu , Yu-Ming Hsu , Chun-Chung Huang , Chih-Yuan Fang , Chuan-Hang Yu , Pin Ju Chueh , Cheng-Chia Yu , Shiao-Pieng Lee

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引用次数: 0

Abstract

Background/purpose

The extract of the soft coral Lobophytum crassum has shown an anti-cancer activity in various cancer cells. However, its effect on the oral squamous cell carcinoma cell (OSCC) lines remains unclear. The purpose of this study is to investigate the anti-cancer effects of the extract of L. crassum (C127) on the OSCC cells.

Materials and methods

This study evaluated the effects of the soft coral extract of L. crassum (C127) on SAS and Ca9-22 cells, cell viability, migration ability, and apoptosis. Electric cell-substrate impedance sensing (ECIS) was parallelly used on SAS cells to confirm the results.

Results

C127 affected cell viability, morphology, and migration ability in both cell lines. In SAS cells, C127 inhibited cell viability in a dose dependent manner (P < 0.001) and induced apoptosis at 10 μg/mL (P < 0.05). In addition, C127 significantly inhibited migration ability on both cell lines in a dose-dependent manner (P < 0.001).

Conclusion

This study illustrated the potential of marine-derived compounds of L. crassum on its activity against OSCC cells.

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软珊瑚 Lobophytum crassum 提取物抑制人口腔鳞状细胞癌细胞迁移并诱导其凋亡的能力

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来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.