The Role of MicroRNAs in regulating genes related to neurodegenerative diseases

Abstract

Neurodegenerative diseases pose significant challenges to public health worldwide. MicroRNAs (miRNAs) have emerged as critical regulators of gene expression and are implicated in the pathogenesis of various neurodegenerative disorders. This review comprehensively explores the current understanding of how miRNAs influence gene networks involved in Alzheimer disease, Parkinson disease and amyotrophic lateral sclerosis. We discuss the mechanisms by which miRNAs modulate disease associated genes, their potential as diagnostic biomarkers, and therapeutic targets in neurodegeneration.