A sbiT-sbiRS-gloIo regulatory circuit is involved in oxidative stress tolerance of Stenotrophomonas maltophilia

IF 4.5 2区医学 Q2 IMMUNOLOGY

Journal of Microbiology Immunology and Infection Pub Date : 2024-07-14 DOI:10.1016/j.jmii.2024.07.005

Cheng-Mu Wu , Yi-Tzu Lee , Hsu-Feng Lu , Yen-Ling Lin , Tsuey-Ching Yang

引用次数: 0

Abstract

The sbiT-sbiR-sbiS operon of Stenotrophomonas maltophilia encodes an inner-membrane protein SbiT and a SbiS-SbiR two-component regulatory system. A sbiT mutant displayed a growth defect in LB agar. Mechanism studies revealed that sbiT deletion resulted in SbiSR activation and gloIo upregulation, which increased intracellular ROS level and caused growth defect.

查看原文本刊更多论文

sbiT-sbiRS-gloIo调控回路参与了嗜麦芽霉菌的氧化应激耐受性

嗜麦芽气单胞菌的 sbiT-sbiR-sbiS 操作子编码内膜蛋白 SbiT 和 SbiS-SbiR 双组分调控系统。sbiT 突变体在 LB 琼脂中显示出生长缺陷。机理研究发现，sbiT缺失导致SbiSR激活和gloIo上调，从而增加了细胞内ROS水平，造成生长缺陷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Microbiology Immunology and Infection IMMUNOLOGY-INFECTIOUS DISEASES

CiteScore

15.90

自引率

5.40%

发文量

159

审稿时长

67 days

期刊介绍： Journal of Microbiology Immunology and Infection is an open access journal, committed to disseminating information on the latest trends and advances in microbiology, immunology, infectious diseases and parasitology. Article types considered include perspectives, review articles, original articles, brief reports and correspondence. With the aim of promoting effective and accurate scientific information, an expert panel of referees constitutes the backbone of the peer-review process in evaluating the quality and content of manuscripts submitted for publication.